File:TGF-B Signalling - Formation of Receptor Hetero-Tetramers.png
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TGF-B Signalling - Formation of Receptor Hetero-Tetramers
The active form of the TGF-β ligand is a dimer of two molecules held together by hydrophobic interactions and a disulfide bond [30,31]. This dimer induces the formation, at the plasma membrane, of receptor hetero-tetramers that contain two type I and two type II receptors [2,3]. The type II receptors phosphorylate the type I receptors; the type I receptors are then enabled to phosphorylate cytoplasmic R-Smads, which then act as transcriptional regulators.
References
<pubmed>16446785</pubmed>
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