File:TBX1 factor figure.jpg

Cardiac neural crest cell defects in Tbx1 mutant embryos. (A) E9.5 Tbx1CRE-RosaYFP embryos were stained for the cNCC marker AP2α together with YFP as a marker for the Tbx1-lineage. cNCCs and Tbx1 do not colocalize (arrowheads). (B) E12.5 Tbx1+/+, Tbx1+/− and Tbx1neo2/− outflow tracts were stained for the cNCC marker Sema3C. cNCCs have migrated into the outflow tract cushions in Tbx1+/+ and Tbx1+/− but not in Tbx1neo2/− embryos. White arrowheads and arrows indicate Sema3C expression in myocardial cuff cells and the septal bridge area, respectively. Asterisk indicates absent Sema3C in the outflow tract right cushion. Yellow arrow marks residual Sema3C-positive cNCCs in the outflow tract left cushion. Scale Bars are in μm.

Reference

Illustration obtained from

Copyright

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

z5229281

This image was originally uploaded as part of an undergraduate science student project and may contain inaccuracies in either description or acknowledgements. Students have been advised in writing concerning the reuse of content and may accidentally have misunderstood the original terms of use. If image reuse on this non-commercial educational site infringes your existing copyright, please contact the site editor for immediate removal.