File:Swapping mitochondrial DNA mammalian oocytes.jpg: Difference between revisions
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Technique has the potential to prevent transmission of human mutated mitochondrial DNA from mother to baby. | Technique has the potential to prevent transmission of human mutated mitochondrial DNA from mother to baby. | ||
Working with rhesus macaque monkeys, Tachibana et al.: | Working with rhesus macaque monkeys, Tachibana et al.<ref><pubmed>19710649</pubmed></ref>: | ||
* '''a''' - removed the nuclear material plus a cellular membrane (a karyoplast) from a mature oocyte, leaving behind its mitochondria. The nuclear material in the karyoplast consists of condensed chromosomes attached to thread-like spindle fibres (the spindle–chromosomal complex). | * '''a''' - removed the nuclear material plus a cellular membrane (a karyoplast) from a mature oocyte, leaving behind its mitochondria. The nuclear material in the karyoplast consists of condensed chromosomes attached to thread-like spindle fibres (the spindle–chromosomal complex). | ||
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===Reference=== | ===Reference=== | ||
<references/> | |||
<pubmed>19759608</pubmed> | <pubmed>19759608</pubmed> | ||
Revision as of 22:02, 8 April 2014
Swapping mitochondrial DNA in mammalian oocytes
Technique has the potential to prevent transmission of human mutated mitochondrial DNA from mother to baby.
Working with rhesus macaque monkeys, Tachibana et al.[1]:
- a - removed the nuclear material plus a cellular membrane (a karyoplast) from a mature oocyte, leaving behind its mitochondria. The nuclear material in the karyoplast consists of condensed chromosomes attached to thread-like spindle fibres (the spindle–chromosomal complex).
- b - transferred the karyoplast to an oocyte whose nucleus had been removed (a cytoplast).
- c - fused the karyoplast with the cytoplast and then fertilized the reconstructed oocyte.
- d - developing blastocyst was implanted in a surrogate mother.
- e - mother gave birth to a healthy baby.
Reference
- ↑ <pubmed>19710649</pubmed>
<pubmed>19759608</pubmed>
Nature 461, 354-355 (17 September 2009) | doi:10.1038/461354a; Published online 16 September 2009
Original Image Link: http://www.nature.com/nature/journal/v461/n7262/fig_tab/461354a_F1.html
Rightslink / Nature Publishing Group Order Details
Licensee: Mark A Hill
License Date: Sep 17, 2009
License Number: 2271631413678
Publication: Nature
Title: Developmental biology: Asexual healing
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