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[[Category:Assisted Reproductive Technology]][[Category: Monkey]] | [[Category:Assisted Reproductive Technology]][[Category: Monkey]] [[Category:Mitochondria]] |
Revision as of 09:57, 11 October 2013
Swapping mitochondrial DNA in mammalian oocytes
Working with rhesus macaque monkeys, Tachibana et al. removed the nuclear material plus a cellular membrane (a karyoplast) from a mature oocyte, leaving behind its mitochondria (a).
They transferred the karyoplast to an oocyte whose nucleus had been removed (a cytoplast; b).
The nuclear material in the karyoplast consists of condensed chromosomes attached to thread-like spindle fibres (the spindle–chromosomal complex). The authors fused the karyoplast with the cytoplast and then fertilized the reconstructed oocyte (c).
The developing blastocyst (d) was implanted in a surrogate mother, which gave birth to a healthy baby (e). This technique has the potential to prevent transmission of human mutated mitochondrial DNA from mother to baby.
Reference
<pubmed>19759608</pubmed>
Nature 461, 354-355 (17 September 2009) | doi:10.1038/461354a; Published online 16 September 2009
Original Image Link: http://www.nature.com/nature/journal/v461/n7262/fig_tab/461354a_F1.html
Rightslink / Nature Publishing Group Order Details
Licensee: Mark A Hill
License Date: Sep 17, 2009
License Number: 2271631413678
Publication: Nature
Title: Developmental biology: Asexual healing
Type Of Use: Web Site
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