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Swapping mitochondrial DNA in mammalian oocytes

Working with rhesus macaque monkeys, Tachibana et al. removed the nuclear material plus a cellular membrane (a karyoplast) from a mature oocyte, leaving behind its mitochondria (a).

They transferred the karyoplast to an oocyte whose nucleus had been removed (a cytoplast; b).

The nuclear material in the karyoplast consists of condensed chromosomes attached to thread-like spindle fibres (the spindle–chromosomal complex). The authors fused the karyoplast with the cytoplast and then fertilized the reconstructed oocyte (c).

The developing blastocyst (d) was implanted in a surrogate mother, which gave birth to a healthy baby (e). This technique has the potential to prevent transmission of human mutated mitochondrial DNA from mother to baby.

Reference

Nature 461, 354-355 (17 September 2009) | doi:10.1038/461354a; Published online 16 September 2009

Original Image Link: http://www.nature.com/nature/journal/v461/n7262/fig_tab/461354a_F1.html

Rightslink / Nature Publishing Group Order Details

Licensee: Mark A Hill

License Date: Sep 17, 2009

License Number: 2271631413678

Publication: Nature

Title: Developmental biology: Asexual healing

Type Of Use: Web Site

Total: $0.00

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	Date/Time	Thumbnail	Dimensions	User	Comment
current	11:47, 18 September 2009		700 × 380 (44 KB)	S8600021 (talk \| contribs)	Swapping mitochondrial DNA in mammalian oocytes :"Working with rhesus macaque monkeys, Tachibana et al. removed the nuclear material plus a cellular membrane (a karyoplast) from a mature oocyte, leaving behind its mitochondria (a). They transferred the k

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 ==Swapping mitochondrial DNA in mammalian oocytes==
-:"Working with rhesus macaque monkeys, Tachibana et al. removed the nuclear material plus a cellular membrane (a karyoplast) from a mature oocyte, leaving behind its mitochondria (a). They transferred the karyoplast to an oocyte whose nucleus had been removed (a cytoplast; b). The nuclear material in the karyoplast consists of condensed chromosomes attached to thread-like spindle fibres (the spindle–chromosomal complex). The authors fused the karyoplast with the cytoplast and then fertilized the reconstructed oocyte (c). The developing blastocyst (d) was implanted in a surrogate mother, which gave birth to a healthy baby (e). This technique has the potential to prevent transmission of human mutated mitochondrial DNA from mother to baby."
+Working with rhesus macaque monkeys, Tachibana et al. removed the nuclear material plus a cellular membrane (a karyoplast) from a mature oocyte, leaving behind its mitochondria (a).
+They transferred the karyoplast to an oocyte whose nucleus had been removed (a cytoplast; b).
+The nuclear material in the karyoplast consists of condensed chromosomes attached to thread-like spindle fibres (the spindle–chromosomal complex). The authors fused the karyoplast with the cytoplast and then fertilized the reconstructed oocyte (c).
+The developing blastocyst (d) was implanted in a surrogate mother, which gave birth to a healthy baby (e). This technique has the potential to prevent transmission of human mutated mitochondrial DNA from mother to baby.