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Swapping mitochondrial DNA in mammalian oocytes
==Swapping mitochondrial DNA in mammalian oocytes==


:"Working with rhesus macaque monkeys, Tachibana et al. removed the nuclear material plus a cellular membrane (a karyoplast) from a mature oocyte, leaving behind its mitochondria (a). They transferred the karyoplast to an oocyte whose nucleus had been removed (a cytoplast; b). The nuclear material in the karyoplast consists of condensed chromosomes attached to thread-like spindle fibres (the spindle–chromosomal complex). The authors fused the karyoplast with the cytoplast and then fertilized the reconstructed oocyte (c). The developing blastocyst (d) was implanted in a surrogate mother, which gave birth to a healthy baby (e). This technique has the potential to prevent transmission of human mutated mitochondrial DNA from mother to baby."
:"Working with rhesus macaque monkeys, Tachibana et al. removed the nuclear material plus a cellular membrane (a karyoplast) from a mature oocyte, leaving behind its mitochondria (a). They transferred the karyoplast to an oocyte whose nucleus had been removed (a cytoplast; b). The nuclear material in the karyoplast consists of condensed chromosomes attached to thread-like spindle fibres (the spindle–chromosomal complex). The authors fused the karyoplast with the cytoplast and then fertilized the reconstructed oocyte (c). The developing blastocyst (d) was implanted in a surrogate mother, which gave birth to a healthy baby (e). This technique has the potential to prevent transmission of human mutated mitochondrial DNA from mother to baby."
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Rightslink / Nature Publishing Group Order Details
Rightslink / Nature Publishing Group Order Details
Licensee: Mark A Hill
Licensee: Mark A Hill
License Date: Sep 17, 2009
License Date: Sep 17, 2009
License Number: 2271631413678
License Number: 2271631413678
Publication: Nature
Publication: Nature
Title: Developmental biology: Asexual healing
Title: Developmental biology: Asexual healing
Type Of Use: Web Site
Type Of Use: Web Site
Total: $0.00
Total: $0.00

Revision as of 01:09, 10 October 2012

Swapping mitochondrial DNA in mammalian oocytes

"Working with rhesus macaque monkeys, Tachibana et al. removed the nuclear material plus a cellular membrane (a karyoplast) from a mature oocyte, leaving behind its mitochondria (a). They transferred the karyoplast to an oocyte whose nucleus had been removed (a cytoplast; b). The nuclear material in the karyoplast consists of condensed chromosomes attached to thread-like spindle fibres (the spindle–chromosomal complex). The authors fused the karyoplast with the cytoplast and then fertilized the reconstructed oocyte (c). The developing blastocyst (d) was implanted in a surrogate mother, which gave birth to a healthy baby (e). This technique has the potential to prevent transmission of human mutated mitochondrial DNA from mother to baby."

Original Image Link: http://www.nature.com/nature/journal/v461/n7262/fig_tab/461354a_F1.html


Rightslink / Nature Publishing Group Order Details

Licensee: Mark A Hill

License Date: Sep 17, 2009

License Number: 2271631413678

Publication: Nature

Title: Developmental biology: Asexual healing

Type Of Use: Web Site

Total: $0.00

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current12:47, 18 September 2009Thumbnail for version as of 12:47, 18 September 2009700 × 380 (44 KB)S8600021 (talk | contribs)Swapping mitochondrial DNA in mammalian oocytes :"Working with rhesus macaque monkeys, Tachibana et al. removed the nuclear material plus a cellular membrane (a karyoplast) from a mature oocyte, leaving behind its mitochondria (a). They transferred the k