File:Swapping mitochondrial DNA mammalian oocytes.jpg: Difference between revisions
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Swapping mitochondrial DNA in mammalian oocytes | ==Swapping mitochondrial DNA in mammalian oocytes== | ||
:"Working with rhesus macaque monkeys, Tachibana et al. removed the nuclear material plus a cellular membrane (a karyoplast) from a mature oocyte, leaving behind its mitochondria (a). They transferred the karyoplast to an oocyte whose nucleus had been removed (a cytoplast; b). The nuclear material in the karyoplast consists of condensed chromosomes attached to thread-like spindle fibres (the spindle–chromosomal complex). The authors fused the karyoplast with the cytoplast and then fertilized the reconstructed oocyte (c). The developing blastocyst (d) was implanted in a surrogate mother, which gave birth to a healthy baby (e). This technique has the potential to prevent transmission of human mutated mitochondrial DNA from mother to baby." | :"Working with rhesus macaque monkeys, Tachibana et al. removed the nuclear material plus a cellular membrane (a karyoplast) from a mature oocyte, leaving behind its mitochondria (a). They transferred the karyoplast to an oocyte whose nucleus had been removed (a cytoplast; b). The nuclear material in the karyoplast consists of condensed chromosomes attached to thread-like spindle fibres (the spindle–chromosomal complex). The authors fused the karyoplast with the cytoplast and then fertilized the reconstructed oocyte (c). The developing blastocyst (d) was implanted in a surrogate mother, which gave birth to a healthy baby (e). This technique has the potential to prevent transmission of human mutated mitochondrial DNA from mother to baby." | ||
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Rightslink / Nature Publishing Group Order Details | Rightslink / Nature Publishing Group Order Details | ||
Licensee: Mark A Hill | Licensee: Mark A Hill | ||
License Date: Sep 17, 2009 | License Date: Sep 17, 2009 | ||
License Number: 2271631413678 | License Number: 2271631413678 | ||
Publication: Nature | Publication: Nature | ||
Title: Developmental biology: Asexual healing | Title: Developmental biology: Asexual healing | ||
Type Of Use: Web Site | Type Of Use: Web Site | ||
Total: $0.00 | Total: $0.00 |
Revision as of 01:09, 10 October 2012
Swapping mitochondrial DNA in mammalian oocytes
- "Working with rhesus macaque monkeys, Tachibana et al. removed the nuclear material plus a cellular membrane (a karyoplast) from a mature oocyte, leaving behind its mitochondria (a). They transferred the karyoplast to an oocyte whose nucleus had been removed (a cytoplast; b). The nuclear material in the karyoplast consists of condensed chromosomes attached to thread-like spindle fibres (the spindle–chromosomal complex). The authors fused the karyoplast with the cytoplast and then fertilized the reconstructed oocyte (c). The developing blastocyst (d) was implanted in a surrogate mother, which gave birth to a healthy baby (e). This technique has the potential to prevent transmission of human mutated mitochondrial DNA from mother to baby."
Original Image Link: http://www.nature.com/nature/journal/v461/n7262/fig_tab/461354a_F1.html
Rightslink / Nature Publishing Group Order Details
Licensee: Mark A Hill
License Date: Sep 17, 2009
License Number: 2271631413678
Publication: Nature
Title: Developmental biology: Asexual healing
Type Of Use: Web Site
Total: $0.00
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