File:Spleen structure 01.jpg
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Spleen Structure
Schematic representation of the organization of the spleen (left panel).
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An image of a section of mouse spleen generated using multicolour immunofluoresence microscopy illustrates the organization of the white pulp, red pulp, and MZ (centre panel).
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- The distinct organization of stromal cells in different regions of the spleen is shown by single-colour immunofluoresence staining (right panel).
- Networks of stromal cells and reticular fibres form in the white pulp, including the fibroblastic reticular cells (FRCs) in T cell zones, follicular dendritic cells (FDCs) in B cell follicles (ER-TR7−) and marginal reticular cells (MRCs) in the MZ.
- A dense network of stromal cells and reticular fibres is present in the red pulp.
Scale bars represent 130 μM.
Reference
<pubmed>19644499</pubmed>| PMC2785037 | Nat Rev Immunol.
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