File:Spleen structure 01.jpg: Difference between revisions
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==Spleen Structure== | ==Spleen Structure== | ||
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Schematic representation of the organization of the spleen (left panel). | | Schematic representation of the organization of the spleen (left panel). | ||
* The white pulp consists of T cell (lymphocyte) zones (also known as the periarteriolar lymphoid sheath (PALS)) containing networks of fibroblastic reticular cells (FRC) surrounding a central arteriole, together with B cell follicles containing a central network of follicular dendritic cells (FDC). | * The white pulp consists of T cell (lymphocyte) zones (also known as the periarteriolar lymphoid sheath (PALS)) containing networks of fibroblastic reticular cells (FRC) surrounding a central arteriole, together with B cell follicles containing a central network of follicular dendritic cells (FDC). | ||
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* Large numbers of macrophages phagocytose dying or damaged red blood cells in the red pulp (not shown). | * Large numbers of macrophages phagocytose dying or damaged red blood cells in the red pulp (not shown). | ||
* Immune cells enter the white pulp at regions where the T cell zones abut the MZ, known as the MZ bridging channels. | * Immune cells enter the white pulp at regions where the T cell zones abut the MZ, known as the MZ bridging channels. | ||
| An image of a section of mouse spleen generated using multicolour immunofluoresence microscopy illustrates the organization of the white pulp, red pulp, and MZ (centre panel). | |||
An image of a section of mouse spleen generated using multicolour immunofluoresence microscopy illustrates the organization of the white pulp, red pulp, and MZ (centre panel). | |||
* The distribution of cells: | * The distribution of cells: | ||
** '''T cells''' - (white) CD3+ | ** '''T cells''' - (white) CD3+ | ||
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** '''dendritic cells''' - (green) (DCs) CD11c+ | ** '''dendritic cells''' - (green) (DCs) CD11c+ | ||
** '''stromal cells''' - (red) ER-TR7+ | ** '''stromal cells''' - (red) ER-TR7+ | ||
|} | |||
* The distinct organization of stromal cells in different regions of the spleen is shown by single-colour immunofluoresence staining (right panel). | * The distinct organization of stromal cells in different regions of the spleen is shown by single-colour immunofluoresence staining (right panel). |
Revision as of 12:57, 26 February 2012
Spleen Structure
Schematic representation of the organization of the spleen (left panel).
|
An image of a section of mouse spleen generated using multicolour immunofluoresence microscopy illustrates the organization of the white pulp, red pulp, and MZ (centre panel).
|
- The distinct organization of stromal cells in different regions of the spleen is shown by single-colour immunofluoresence staining (right panel).
- Networks of stromal cells and reticular fibres form in the white pulp, including the fibroblastic reticular cells (FRCs) in T cell zones, follicular dendritic cells (FDCs) in B cell follicles (ER-TR7−) and marginal reticular cells (MRCs) in the MZ.
- A dense network of stromal cells and reticular fibres is present in the red pulp.
Scale bars represent 130 μM.
Reference
<pubmed>19644499</pubmed>| PMC2785037 | Nat Rev Immunol.
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