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Pancreatic growth and cell differentiation require SOX9 activity. Hematoxylin/eosin (H&E) staining of pancreatic sections from E18.5 embryos (A and B) shows that pancreatic rudiments from Sox9flox/flox;Pdx1-Cre (Sox9Δpan/Δpan) embryos comprise predominantly fibrous tissue and epithelial cysts surrounding isolated clusters of acini, some of which show densely packed nuclei (B Inset). Sox9Δpan/Δpan pancreatic rudiments display an almost complete absence of insulin+, glucagon+, somatostatin+, or pancreatic polypeptide+ endocrine cells (D and F) and scattered acinar cells that are weakly amylase+ (H). INS, insulin; GLU, glucagon; SOM, somatostatin; PP, pancreatic polypeptide; AMY, amylase; e, embryonic day. (Scale bar, 100 μm.)

<pubmed>17267606</pubmed>

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