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The PNAS listing on the Sherpa RoMEO publisher copyright policies & self-archiving detail pages can be found here. | The PNAS listing on the Sherpa RoMEO publisher copyright policies & self-archiving detail pages can be found here. | ||
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Revision as of 21:53, 2 October 2012
Pancreatic growth and cell differentiation require SOX9 activity. Hematoxylin/eosin (H&E) staining of pancreatic sections from E18.5 embryos (A and B) shows that pancreatic rudiments from Sox9flox/flox;Pdx1-Cre (Sox9Δpan/Δpan) embryos comprise predominantly fibrous tissue and epithelial cysts surrounding isolated clusters of acini, some of which show densely packed nuclei (B Inset). Sox9Δpan/Δpan pancreatic rudiments display an almost complete absence of insulin+, glucagon+, somatostatin+, or pancreatic polypeptide+ endocrine cells (D and F) and scattered acinar cells that are weakly amylase+ (H). INS, insulin; GLU, glucagon; SOM, somatostatin; PP, pancreatic polypeptide; AMY, amylase; e, embryonic day. (Scale bar, 100 μm.)
<pubmed>17267606</pubmed>
Copyright and License to Publish Beginning with articles submitted in Volume 106 (2009) the author(s) retains copyright to individual articles, and the National Academy of Sciences of the United States of America retains an exclusive license to publish these articles and holds copyright to the collective work. Volumes 90–105 (1993–2008), copyright © by the National Academy of Sciences. Volumes 1–89 (1915–1992), the author(s) retains copyright to individual articles, and the National Academy of Sciences holds copyright to the collective work. The PNAS listing on the Sherpa RoMEO publisher copyright policies & self-archiving detail pages can be found here.
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