File:Signalling pathways in heart development.png: Difference between revisions

Description

Signalling pathways involved in heart development Overview of the signaling pathways that have been implicated into cardiogenic induction. Endoderm-derived signals (labeled in green: BMP2, FGF8, Crescent, and Shh/Ihh) act as inducers of cardiac mesoderm formation (characterized by the induction of a battery of cardiogenic transcription factors, such as Nkx2.5, GATA factors, myocardin, and Tbx20). Inhibitory signals are mesoderm-derived [labeled in red; Chordin, Noggin, Wnt1, −3,− 8, and Serrate (Ser)]. The role of Nodal or related signaling molecules is inferred from the fact that zebrafish mutants of the competence factor oep have small hearts and oeplspadetail mutants lack a heart altogether. Wnt11 is a potent cardiac inducer that is present in mesoderm. The neural ectoderm (not depicted here) is a source of inhibitors of heart field formation. Where possible, signal transducers of the particular signaling pathway with a demonstrated function in cardiac induction are indicated (labeled in white).

Reference

<pubmed>12781678</pubmed>
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