Difference between revisions of "File:Role of FXN Gene.jpg"

From Embryology
(A model of how cytosolic iron depletion decreases expression of frataxin in FA patients and may thereby exacerbate disease. Frataxin deficiency mainly caused by the triplet GAA repeat expansion in the first intron of frataxin gene leads to decreased frata)
 
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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Revision as of 12:01, 6 October 2011

A model of how cytosolic iron depletion decreases expression of frataxin in FA patients and may thereby exacerbate disease. Frataxin deficiency mainly caused by the triplet GAA repeat expansion in the first intron of frataxin gene leads to decreased frataxin expression and impairment of mitochondrial iron–sulfur cluster [Fe–S] assembly. Mitochondrial iron overload develops as a consequence of deficient [Fe–S] assembly in mitochondria which leads to misregulation of mitochondrial iron homeostasis. Excess mitochondrial iron uptake and sequestration causes cytosolic iron depletion, which can further diminish frataxin expression by decreasing frataxin transcription. Thus, the decrease in frataxin levels caused by the trinucleotide repeat may be worsened as cells accumulate mitochondrial iron and deplete cytosolic iron stores. This negative feedback loop may contribute to progression of disease in long-lived cells, particularly neurons and cardiomyocytes.



References

<pubmed>2465796</pubmed>| PMC2465796


This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.



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Cite this page: Hill, M.A. (2021, February 27) Embryology Role of FXN Gene.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Role_of_FXN_Gene.jpg

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© Dr Mark Hill 2021, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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