File:Reticular network formation model.jpg
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Model of Reticular Network Formation
- Accumulation of lymphocytes induces alteration of mesenchymal progenitors such that they produce chemokines for further lymphocyte attraction and RF components via the secretion of Tumor necrosis factor-alpha (TNFα) or Lymphotoxin-alpha (LTα) (or related cytokines) and likely also via direct contacts mediated by adhesion molecules and LTα1β2.
- Lymphocytes and differentiated FRCs gradually degrade preexisting matrix, and FRCs weave RF meshwork from the newly produced components.
- Mature RN forms and antigen presentation occur on the stromal reticulum.
- LTα exists as either a secreted homotrimer or heterotrimer molecule
- LTα3 homotrimer signals via TNFR1 and TNFR2
- LTα1β2 heterotrimer with LTβ on the cell surface signals through the LTβ receptor (LTβR).
- unique in the TNF superfamily as a biologically active heterotrimer.
- Lymphotoxin (LT) α1β2 induces dimerization rather than trimerization of the LTβ Receptor (LTβR).
- Homotrimeric TNF superfamily ligands signal by inducing trimers of their receptors.
See also PMID 25663676 Figure - Lymph node paracortex fibroblastic reticular cells
Reference
<pubmed>15381731</pubmed>| J Exp Med.
doi: 10.1084/jem.20040254
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Figure 8. panel C cropped from full figure and PMID added.
Cite this page: Hill, M.A. (2024, April 19) Embryology Reticular network formation model.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Reticular_network_formation_model.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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