File:Renal histology 02.jpg
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- Renal System Histology: Nephron tubule overview | glomerulus structure | vascular and renal poles | Medullary rays | Nephron tubules
The glomerulus (or renal corpuscle) in humans is the round (~0.2 mm in diameter) blind beginning of the nephron. It is invaginated by a tuft of capillaries at the vascular pole of the glomerulus. The tuft of capillaries and other cells in contact with them form the anatomical glomerulus. Substances which leave the capillaries enter the renal tubule at the urinary pole of the glomerulus.
The anatomical glomerulus is enclosed by two layers of epithelium, Bowman's capsule.
- Cells of the outer or parietal layer of Bowman's capsule form a simple squamous epithelium.
- Cells of the inner layer, podocytes in the visceral layer, are extremely complex in shape. Small foot-like processes, pedicles, of their cytoplasm form a fenestrated epithelium around the fenestrated capillaries of the glomerulus. The openings between the pedicles are called filtration slits. They are spanned by a thin membrane, the filtration slit membrane. Between the podocytes and the endothelial cells of the capillaries we find a comparatively thick basal lamina, which can be subdivided into an outer lamina rara externa, a middle lamina densa and an inner lamina rara interna. The basal lamina and the slit membranes form the glomerular filtration barrier, which prevents some large molecules from entering the capsular space between the outer and inner epithelial layers of Bowman's capsule.
- Mesangial cells in the glomerulus form the connective tissue that gives structural support to podocytes and vessels.
- Blood pressure is the driving force in the formation of about 125 ml of glomerular filtrate per minute.
- About 124 ml of the glomerular filtrate is reabsorbed in the tubules of the nephron.
Links: Histology | Histology Stains | Blue Histology images copyright Lutz Slomianka 1998-2009. The literary and artistic works on the original Blue Histology website may be reproduced, adapted, published and distributed for non-commercial purposes. See also the page Histology Stains.
Cite this page: Hill, M.A. (2021, December 2) Embryology Renal histology 02.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Renal_histology_02.jpg
- © Dr Mark Hill 2021, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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