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=Regulation of Nodal gradient and signalling activity=
===Description===
 
''Figure 11''
 
====Regulation of Nodal gradient and signalling activity====
A model of signalling activity and gradients in mammals during the early stage of embryonic development provides clues for designing the initial stages of human pluripotent stem cells (hPSC) to cardiomyocyte differentiation. Nodal/Activin regulation is mediated by high Nodal production in epiblast cells, timed secretion of Nodal antagonists (cerberus and LEFTY1) by regions of the visceral endoderm, and autoregulatory feedback loops involving BMP4 and Wnt3 in proximal extraembryonic tissue.  
A model of signalling activity and gradients in mammals during the early stage of embryonic development provides clues for designing the initial stages of human pluripotent stem cells (hPSC) to cardiomyocyte differentiation. Nodal/Activin regulation is mediated by high Nodal production in epiblast cells, timed secretion of Nodal antagonists (cerberus and LEFTY1) by regions of the visceral endoderm, and autoregulatory feedback loops involving BMP4 and Wnt3 in proximal extraembryonic tissue.  


Copyright: Articles published in these journals are in the public domain and may be used and reproduced without special permission. However, anyone using the material is requested to properly cite and acknowledge the source <pubmed>25813860 </pubmed>
===Reference===
<pubmed>25813860 </pubmed>
 
===Copyright===
Articles published in these journals are in the public domain and may be used and reproduced without special permission. However, anyone using the material is requested to properly cite and acknowledge the source.
 
 
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{{Template:Student Image}}

Revision as of 12:14, 13 October 2017

Description

Figure 11

Regulation of Nodal gradient and signalling activity

A model of signalling activity and gradients in mammals during the early stage of embryonic development provides clues for designing the initial stages of human pluripotent stem cells (hPSC) to cardiomyocyte differentiation. Nodal/Activin regulation is mediated by high Nodal production in epiblast cells, timed secretion of Nodal antagonists (cerberus and LEFTY1) by regions of the visceral endoderm, and autoregulatory feedback loops involving BMP4 and Wnt3 in proximal extraembryonic tissue.

Reference

<pubmed>25813860 </pubmed>

Copyright

Articles published in these journals are in the public domain and may be used and reproduced without special permission. However, anyone using the material is requested to properly cite and acknowledge the source.



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