File:Pronuclear transfer.jpg
From Embryology
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Diagram of pronuclear transfer
- Create an zygote using the parents’ sperm and eggs .
- At the same time, a second Zygote is created using a donor egg with healthy mitochondria and the father’s (or donor) sperm.
- The pronuclei are removed from the single-cell stage embryo (day one). The leftover enucleated embryo with diseased mitochondria is discarded.
- The pronuclei of the second embryo are removed and discarded.
- The parents’ pronuclei can be placed into the second embryo for development.
- The developed embryo will then be transferred into the mother.
Reference
<pubmed> 25573721 </pubmed>
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