File:PMID28514120-Chen et al-2017.pdf

From Embryology
Revision as of 11:13, 11 May 2019 by Z8600021 (talk | contribs)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)

PMID28514120-Chen_et_al-2017.pdf(file size: 2.87 MB, MIME type: application/pdf)

Mouth Development

A mouth is present in all animals, and comprises an opening from the outside into the oral cavity and the beginnings of the digestive tract to allow eating. This review focuses on the earliest steps in mouth formation. In the first half, we conclude that the mouth arose once during evolution. In all animals, the mouth forms from ectoderm and endoderm. A direct association of oral ectoderm and digestive endoderm is present even in triploblastic animals, and in chordates, this region is known as the extreme anterior domain (EAD). Further support for a single origin of the mouth is a conserved set of genes that form a 'mouth gene program' including foxA and otx2. In the second half of this review, we discuss steps involved in vertebrate mouth formation, using the frog Xenopus as a model. The vertebrate mouth derives from oral ectoderm from the anterior neural ridge, pharyngeal endoderm and cranial neural crest (NC). Vertebrates form a mouth by breaking through the body covering in a precise sequence including specification of EAD ectoderm and endoderm as well as NC, formation of a 'pre-mouth array,' basement membrane dissolution, stomodeum formation, and buccopharyngeal membrane perforation. In Xenopus, the EAD is also a craniofacial organizer that guides NC, while reciprocally, the NC signals to the EAD to elicit its morphogenesis into a pre-mouth array. Human mouth anomalies are prevalent and are affected by genetic and environmental factors, with understanding guided in part by use of animal models.


Chen J, Jacox LA, Saldanha F & Sive H. (2017). Mouth development. Wiley Interdiscip Rev Dev Biol , 6, . PMID: 28514120 DOI.


© 2017 The Authors. WIREs Developmental Biology published by Wiley Periodicals, Inc.

You are free to: Share — copy and redistribute the material in any medium or format

Cite this page: Hill, M.A. (2024, June 22) Embryology PMID28514120-Chen et al-2017.pdf. Retrieved from

What Links Here?
© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

File history

Yi efo/eka'e gwa ebo wo le nyangagi wuncin ye kamina wunga tinya nan

current11:11, 11 May 2019 (2.87 MB)Z8600021 (talk | contribs)===Reference=== Mouth development Wiley Interdiscip Rev Dev Biol. 2017 Sep;6(5). doi: 10.1002/wdev.275. Epub 2017 May 17. Chen J1,2, Jacox LA1,3,4, Saldanha F1, Sive H1,2. A mouth is present in all animals, and comprises an opening from the outside i...

The following page uses this file: