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Diagram of Polar body 1 transfer in in-vitro fertilizatio
=Diagram of Polar body 1 transfer in in-vitro fertilization=
 
Polar bodies are small cells formed during the meiotic reductive division of the oocyte. they contains complementary choromosomes (to the mature oocyte) and small amount of cytoplasmic segregation
 
* The Polar Body 1 of patient's egg is removed for transfer to the donor egg. The leftover egg, which contains the unhealthy mitochondria, is then discarded.
* a donated egg is also extracted from an unrelated woman who has healthy mitochondria. Similarly, the chromosomes of the donor’s egg are removed. However, these chromosomes are discarded, leaving behind the healthy mitochondria in the cytoplasm.
* The Polar body 1 previously taken from the patient's egg are inserted into the enucleated donor’s egg.
*The resulting reconstructed egg contains nuclear DNA from the mother and the healthy mitochondria from the donor.
*The resulting egg can now be fertilized with sperm from the intended father. The resulting embryo will be implanted into the intending mother and will develop unaffected by inherited mitochondrial disease.
 
=Reference=
<pubmed> 25472922 </pubmed>
 
=copyright=
 
Copyright © z3251292.  permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 
 
{{Student Image}}

Latest revision as of 15:20, 22 October 2015

Diagram of Polar body 1 transfer in in-vitro fertilization

Polar bodies are small cells formed during the meiotic reductive division of the oocyte. they contains complementary choromosomes (to the mature oocyte) and small amount of cytoplasmic segregation

  • The Polar Body 1 of patient's egg is removed for transfer to the donor egg. The leftover egg, which contains the unhealthy mitochondria, is then discarded.
  • a donated egg is also extracted from an unrelated woman who has healthy mitochondria. Similarly, the chromosomes of the donor’s egg are removed. However, these chromosomes are discarded, leaving behind the healthy mitochondria in the cytoplasm.
  • The Polar body 1 previously taken from the patient's egg are inserted into the enucleated donor’s egg.
  • The resulting reconstructed egg contains nuclear DNA from the mother and the healthy mitochondria from the donor.
  • The resulting egg can now be fertilized with sperm from the intended father. The resulting embryo will be implanted into the intending mother and will develop unaffected by inherited mitochondrial disease.

Reference

<pubmed> 25472922 </pubmed>

copyright

Copyright © z3251292. permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.



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