View source for File:Ngn1 and Ngn2 in DRG development.png


Normal expression of neurogenins in Rbpj-deficient DRG. (A-L) Transverse sections through the upper neural tube (nt) and surrounding tissue of wild-type (WT) and Rbpj CKO with Ngn1 (A-F) and Ngn2 (G-L) mRNA probes at the indicated stages. Loss of Rbpj does not appear to affect the expression of neurogenins either in migrating NCCs at E9.5 and E10.0, or in post-migratory NCCs in the DRG at E10.0 and E10.5. Arrows in (A,B,G,H) point to a cluster of migrating NCCs, and those in (C-F,I-L) point to post-migratory NCCs condensed in the DRG located laterally to the neural tube. High magnification views of the areas delineated by black rectangles in panels (C-F,I,J) are shown at the bottom of each panel. Note that the signal of in situ hybridization is present in the cytoplasm, whereas the nuclei contain no signals. 

==Reference==

Hu, Z.-L., Shi, M., Huang, Y., Zheng, M.-H., Pei, Z., Chen, J.-Y., … Ding, Y.-Q. (2011). The role of the transcription factor Rbpj in the development of dorsal root ganglia. Neural Development, 6, 14. http://doi.org/10.1186/1749-8104-6-14

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