File:Mouse telencephalon radial glia model.jpg

Mouse Telencephalon Radial Glia Model

Changes to radial progenitors and their progeny in Dicer1-/- telencephalon.

• At E10.25 the telencephalon comprises the neuroepithelial stem cells “1” which express stem cell markers Sox2, Musashi, CD133.
• Expression of these proteins is maintained throughout their undifferentiated state. By E11.5, the neuroepithelial stem cells establish the radial glia “2”.
• Basal progenitors “3” and neurons “4, 5” are two classes of progeny generated by radial glia around E11.5. * Dicer deficient neuroepithelium does not establish the appropriate molecular signature of radial glia at E11.5, which normally strongly express Nestin and Sox9 proteins.
• The proportion of Tbr2 positive basal progenitors is increased in Dicer1-/- telencephalon while the proportions of early postmitotic neurons labelled with TuJ1 and HuC/D or differentiated Tbr1 positive neurons are unchanged.
• The laminar organisation of both basal progenitors and neurons is disrupted following the loss of functional Dicer.

Original file name: Figure 6. Journal.pone.0023013.g006.jpg dpi:10.1371/journal.pone.0023013.g006

Reference

Nowakowski TJ, Mysiak KS, Pratt T, Price DJ (2011) Functional Dicer Is Necessary for Appropriate Specification of Radial Glia during Early Development of Mouse Telencephalon. PLoS ONE 6(8): e23013. doi:10.1371/journal.pone.0023013 PloS One.

Copyright: © 2011 Nowakowski et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.