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* The laminar organisation of both basal progenitors and neurons is disrupted following the loss of functional Dicer.
* The laminar organisation of both basal progenitors and neurons is disrupted following the loss of functional Dicer.
{{Mouse E days}}


===Reference===
===Reference===

Revision as of 12:39, 28 June 2018

Mouse Telencephalon Radial Glia Model

Changes to radial progenitors and their progeny in Dicer1-/- telencephalon.

  • At E10.25 the telencephalon comprises the neuroepithelial stem cells “1” which express stem cell markers Sox2, Musashi, CD133.


  • Expression of these proteins is maintained throughout their undifferentiated state. By E11.5, the neuroepithelial stem cells establish the radial glia “2”.


  • Basal progenitors “3” and neurons “4, 5” are two classes of progeny generated by radial glia around E11.5.


  • Dicer deficient neuroepithelium does not establish the appropriate molecular signature of radial glia at ME11.5, which normally strongly express Nestin and Sox9 proteins.


  • The proportion of Tbr2 positive basal progenitors is increased in Dicer1-/- telencephalon while the proportions of early postmitotic neurons labelled with TuJ1 and HuC/D or differentiated Tbr1 positive neurons are unchanged.


  • The laminar organisation of both basal progenitors and neurons is disrupted following the loss of functional Dicer.
Mouse Stages: E1 | E2.5 | E3.0 | E3.5 | E4.5 | E5.0 | E5.5 | E6.0 | E7.0 | E7.5 | E8.0 | E8.5 | E9.0 | E9.5 | E10 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E17.5 | E18 | E18.5 | E19 | E20 | Timeline | About timed pregnancy


Species Embryonic Comparison Timeline
Carnegie Stage
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
Human Days 1 2-3 4-5 5-6 7-12 13-15 15-17 17-19 20 22 24 28 30 33 36 40 42 44 48 52 54 55 58
Mouse Days 1 2 3 E4.5 E5.0 E6.0 E7.0 E8.0 E9.0 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16
Rat Days 1 3.5 4-5 5 6 7.5 8.5 9 10.5 11 11.5 12 12.5 13 13.5 14 14.5 15 15.5 16 16.5 17 17.5
Note these Carnegie stages are only approximate day timings for average of embryos. Links: Carnegie Stage Comparison
Table References  
Human

O'Rahilly R. (1979). Early human development and the chief sources of information on staged human embryos. Eur. J. Obstet. Gynecol. Reprod. Biol. , 9, 273-80. PMID: 400868
Otis EM and Brent R. Equivalent ages in mouse and human embryos. (1954) Anat Rec. 120(1):33-63. PMID 13207763

Mouse
Theiler K. The House Mouse: Atlas of Mouse Development (1972, 1989) Springer-Verlag, NY. Online
OTIS EM & BRENT R. (1954). Equivalent ages in mouse and human embryos. Anat. Rec. , 120, 33-63. PMID: 13207763

Rat
Witschi E. Rat Development. In: Growth Including Reproduction and Morphological Development. (1962) Altman PL. and Dittmer DS. ed. Fed. Am. Soc. Exp. Biol., Washington DC, pp. 304-314.
Pérez-Cano FJ, Franch À, Castellote C & Castell M. (2012). The suckling rat as a model for immunonutrition studies in early life. Clin. Dev. Immunol. , 2012, 537310. PMID: 22899949 DOI.

Timeline Links: human timeline | mouse timeline | mouse detailed timeline | chicken timeline | rat timeline | Medaka | Category:Timeline

Reference

Nowakowski TJ, Mysiak KS, Pratt T & Price DJ. (2011). Functional dicer is necessary for appropriate specification of radial glia during early development of mouse telencephalon. PLoS ONE , 6, e23013. PMID: 21826226 DOI.


Copyright

© 2011 Nowakowski et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Original file name: Figure 6. Journal.pone.0023013.g006.jpg dpi:10.1371/journal.pone.0023013.g006


Cite this page: Hill, M.A. (2024, April 19) Embryology Mouse telencephalon radial glia model.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Mouse_telencephalon_radial_glia_model.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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