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==Model for Generation of Left Isomerism in Ccdc40 versus Shh pathway mutants==
==Mouse Left-Right Axis==
Gastrula stage - Initially perinodal crown cells symmetrically express Nodal, Wnt and their antagonist Cerberus like-2 (Cerl2).
Gastrula stage - Initially perinodal crown cells symmetrically express Nodal, Wnt and their antagonist Cerberus like-2 (Cerl2).


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[[Category:Mouse]][[Category:Mouse E8]][[Category:Developmental Mechanism]][[Category:Cartoon]]
[[Category:Mouse]][[Category:Mouse E8.0]][[Category:Developmental Mechanism]][[Category:Cartoon]]

Latest revision as of 18:08, 30 April 2017

Mouse Left-Right Axis

Gastrula stage - Initially perinodal crown cells symmetrically express Nodal, Wnt and their antagonist Cerberus like-2 (Cerl2).

  • 1-somite stage Cerl2 expression (green) becomes asymmetric with reduced expression on the left side of the node in response to fluid flow. With reduced expression of its antagonist on the left, Nodal activity and expression (dark blue) increases on the left side and decreases on the right.
  • 2-somite stage wild type embryos, Nodal induce Nodal expression in the L-LPM (left lateral plate mesoderm)
  • 3-somite stage robust expression of Nodal along with Lefty1 and Lefty2 (light blue) is detected in the L-LPM and Lefty1 in the midline (light blue).
  • 4-somite stage embryos Nodal expression is reduced but Lefty1 and Lefty2 are strongly expressed in the L-LPM. Lefty1 expression in the midline and Cerl2 around the node inhibits Nodal signaling in the R-LPM.


Links: left-right axis mutants | Nodal | Axes Formation | Gastrulation | Mouse E8.0 | Mouse Development


Mouse E8.0 - (Theiler Stage 12a First Somites unturned embryo with first appearance of somite pairs 1-4 somites. The allantois extends further into the exocoelom and the maxillary components of the 1st branchial arch become prominent. The preotic sulcus is visible in the 2-3 somite embryo. The cardiogenic plate begins to form and the foregut pocket is clearly visible. Embryonic age = 8 dpc (range 7.5-8.75 dpc) 1-7 somite pairs

Mouse Stages: E1 | E2.5 | E3.0 | E3.5 | E4.5 | E5.0 | E5.5 | E6.0 | E7.0 | E7.5 | E8.0 | E8.5 | E9.0 | E9.5 | E10 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E17.5 | E18 | E18.5 | E19 | E20 | Timeline | About timed pregnancy


Species Embryonic Comparison Timeline
Carnegie Stage
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
Human Days 1 2-3 4-5 5-6 7-12 13-15 15-17 17-19 20 22 24 28 30 33 36 40 42 44 48 52 54 55 58
Mouse Days 1 2 3 E4.5 E5.0 E6.0 E7.0 E8.0 E9.0 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16
Rat Days 1 3.5 4-5 5 6 7.5 8.5 9 10.5 11 11.5 12 12.5 13 13.5 14 14.5 15 15.5 16 16.5 17 17.5
Note these Carnegie stages are only approximate day timings for average of embryos. Links: Carnegie Stage Comparison
Table References  
Human

O'Rahilly R. (1979). Early human development and the chief sources of information on staged human embryos. Eur. J. Obstet. Gynecol. Reprod. Biol. , 9, 273-80. PMID: 400868
Otis EM and Brent R. Equivalent ages in mouse and human embryos. (1954) Anat Rec. 120(1):33-63. PMID 13207763

Mouse
Theiler K. The House Mouse: Atlas of Mouse Development (1972, 1989) Springer-Verlag, NY. Online
OTIS EM & BRENT R. (1954). Equivalent ages in mouse and human embryos. Anat. Rec. , 120, 33-63. PMID: 13207763

Rat
Witschi E. Rat Development. In: Growth Including Reproduction and Morphological Development. (1962) Altman PL. and Dittmer DS. ed. Fed. Am. Soc. Exp. Biol., Washington DC, pp. 304-314.
Pérez-Cano FJ, Franch À, Castellote C & Castell M. (2012). The suckling rat as a model for immunonutrition studies in early life. Clin. Dev. Immunol. , 2012, 537310. PMID: 22899949 DOI.

Timeline Links: human timeline | mouse timeline | mouse detailed timeline | chicken timeline | rat timeline | Medaka | Category:Timeline

Reference

<pubmed>28182636</pubmed>

Copyright

© 2017 Sugrue, Zohn. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Fig 6. https://doi.org/10.1371/journal.pone.0171180.g006 Wildtype panel cropped from full figure.


Cite this page: Hill, M.A. (2024, March 28) Embryology Mouse left-right axis 02.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Mouse_left-right_axis_02.jpg

What Links Here?
© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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