File:Mouse E9.5 gene expression.jpg

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Analysis of Mouse Stage E9.5 Specific Gene Expression

1140 transcripts were found to be significantly up-regulated exclusively at one developmental time point. A large fraction of these stage specific genes were found to be novel (A), in particular at E13.5 only 5% of the transcripts had confirmed musculoskeletal knockout phenotypes and 6% of the genes have been validated by in situ hybridization. A survey of available in situ expression profiles for genes with peak expression levels at E9.5 (B), E10.5 (C), E11.5 (D), E12.5 (E) and E13.5 (F) revealed that they display a wide range of patterns, and include closely related members of gene families such as Irx, Smarc and zinc finger transcription factors.


Limb Links: Mouse limb skeleton cartoon | Mouse limb tissue development | Limb Development | Mouse Development
Gene Expression Patterns: E9.5 | E10.5 | E11.5 | E12.5 | E13.5 | Lmx1b | Forelimb | Tbx5 | Fbxo41 | Hoxc5 | Hoxb5 | Prdm1 | Hoxb6 | Etv2 | Egr1 | Figf | Sp6 | Cited1 | Prox1 | SmarcD2 | Echdc1 | Sim2 | Hindlimb | Tbx4 | Ptx1 | Hoxc10 | Hoxc9 | Dmrt2

Reference

Taher L, Collette NM, Murugesh D, Maxwell E, Ovcharenko I & Loots GG. (2011). Global gene expression analysis of murine limb development. PLoS ONE , 6, e28358. PMID: 22174793 DOI.

Copyright

This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

Figure 6. doi:10.1371/journal.pone.0028358.g006

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current19:05, 13 February 2013Thumbnail for version as of 19:05, 13 February 20131,757 × 1,100 (269 KB)Z8600021 (talk | contribs)==Expression Pattern of Fore-limb Specific Gene== Qualitatively some genes identified as forelimb or hindlimb specific do not appear to be restricted to one limb such as Sp6, SmarcD2 and Hoxc10, yet quantitatively these transcripts are >2 fold up-regulate

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