File:Mouse-pancreas duct formation.jpg

Development and banching morphogenesis of the pancreas

Pancreatic specification of polarized endodermal cells leads to the formation of a multilayered and then globular mass of epithelial cells with a central duct lumen (pancreatic bud). This lumen, connected to the gut tube lumen, forms extensions within the pancreatic bud, and is surrounded by several layers of cells, linked by adherens junctions (E-cadherin), but lacking tight junctions (ZO-1).

Around mouse embryo E11.5, before remodeling of the mass, some cells at the periphery acquire apico-basal polarity and delineate blind lumina (secondary lumina). Initial branching morphogenesis events result from the coalescence of secondary and central lumina, allowing the progression towards epithelial monolayers.

Links: pancreas | mouse

Reference

Hick AC, van Eyll JM, Cordi S, Forez C, Passante L, Kohara H, Nagasawa T, Vanderhaeghen P, Courtoy PJ, Rousseau GG, Lemaigre FP & Pierreux CE. (2009). Mechanism of primitive duct formation in the pancreas and submandibular glands: a role for SDF-1. BMC Dev. Biol. , 9, 66. PMID: 20003423 DOI.

Copyright

© 2009 Hick et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Hick et al. BMC Developmental Biology 2009 9:66 doi:10.1186/1471-213X-9-66

http://www.biomedcentral.com/1471-213X/9/66

Cite this page: Hill, M.A. (2024, April 19) Embryology Mouse-pancreas duct formation.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Mouse-pancreas_duct_formation.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G