File:Mouse- embryonic stem cell signaling regulation.jpg

Mouse- embryonic stem cell regulation

Core transcriptional regulatory circuitry in pluripotent mouse ESCs.

Recent papers have demonstrated a role for Krüppel-like transcription factors 2, 4 and 5 in the control of mouse embryonic stem cell pluripotency. However, it is not clear whether each factor has a unique role or whether they are functionally redundant. A paper by Parisi and colleagues in BMC Biology now sheds light on the mechanism by which Klf5 regulates pluripotency.

See article BMC Biol.

Original file name: Figure 1. 1741-7007-8-125-1.jpg

Reference

<pubmed>20875146</pubmed>| PMC2946285 | BMC Biol.

© 2010 Bourillot and Savatier; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.