File:Molecular & Genetic Cardiac Development Factors.jpg: Difference between revisions

Latest revision as of 12:35, 8 October 2014

Molecular Factors in Cardiac Development

Identification of the predominant molecular and genetic factors involved in cardiac development.

Transcription Factors

Nk family transcription factors are expressed in all animals with contractile vascular cells and hence are crucial for myocardial development; Nkx2.5 is specifically required for left ventricular chamber development.
Gata family transcription factors interact with Nk factors to promote differentiation of cardiomyocytes, smooth muscle cells and endoderm; Gata4 regulates myocardial expression and is required for fusion of the heart tubes in the ventral midline; Gata5 is required for endocardial differentiation.
T-box - (Tbx) genes play an important role in cardiac morphogenesis; Tbx1 may play a role in neural crest proliferation/function; Tbx2 plays a significant role in chamber specification; Tbx5 is required for atrial septation.
Pitx2 is a left-sided transcription factor that controls normal cardiac morphogenesis by regulating cell proliferation.

Signalling Molecules

Bone morphogenetic protein - (BMP) (particularly Bmp2) is expressed in cardiogenic mesoderm and is important for specification and myocardial differentiation.
Wnt - signalling inhibition promotes cardiogenesis in the cardiogenic mesoderm.
Fibroblast growth factor - (Fgf) acts alongside Bmp to allow for myocardial differentiation. Fgf8 is expressed in cardiogenic mesoderm and hence allows for cardiac specification.
Notch - signalling establishes sub-populations within the cardiogenic mesoderm by regulating asymmetric cell division. Notch also has an inhibitory effect on myocardial differentiation.
Cripto mediates Nodal signalling to allow for myocardial differentiation.

Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular

Cite this page: Hill, M.A. (2024, April 25) Embryology Molecular & Genetic Cardiac Development Factors.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Molecular_%26_Genetic_Cardiac_Development_Factors.jpg

What Links Here?

File history

Click on a date/time to view the file as it appeared at that time.

	Date/Time	Thumbnail	Dimensions	User	Comment
current	12:09, 14 March 2010		1,475 × 1,541 (269 KB)	Z3212774 (talk \| contribs)	category:Heart ILP Identification of the predominant molecular and genetic factors involved in cardiac development.

You cannot overwrite this file.

File usage

The following 6 pages use this file:

@@ Line 3: / Line 3: @@
 Identification of the predominant molecular and genetic factors involved in cardiac development.
+===Transcription Factors===
+* '''Nk''' family transcription factors are expressed in all animals with contractile vascular cells and hence are crucial for myocardial development; Nkx2.5 is specifically required for left ventricular chamber development.
+* '''Gata''' family transcription factors interact with Nk factors to promote differentiation of cardiomyocytes, smooth muscle cells and endoderm; Gata4 regulates myocardial expression and is required for fusion of the heart tubes in the ventral midline; Gata5 is required for endocardial differentiation.
+* [[Developmental_Signals_-_Tbx|T-box]] - (Tbx) genes play an important role in cardiac morphogenesis; Tbx1 may play a role in neural crest proliferation/function; Tbx2 plays a significant role in chamber specification; Tbx5 is required for atrial septation.
+* '''Pitx2''' is a left-sided transcription factor that controls normal cardiac morphogenesis by regulating cell proliferation.
+===Signalling Molecules===
+* [[Developmental_Signals_-_Bone_Morphogenetic_Protein|Bone morphogenetic protein]] - (BMP) (particularly Bmp2) is expressed in cardiogenic mesoderm and is important for specification and myocardial differentiation.
+* [[Developmental_Signals_-_Wnt|Wnt]] - signalling inhibition promotes cardiogenesis in the cardiogenic mesoderm.
+* [[Developmental_Signals_-_Fibroblast_Growth_Factor|Fibroblast growth factor]] - (Fgf) acts alongside Bmp to allow for myocardial differentiation.  Fgf8 is expressed in cardiogenic mesoderm and hence allows for cardiac specification.
+* [[Developmental_Signals_-_Notch|Notch]] - signalling establishes sub-populations within the cardiogenic mesoderm by regulating asymmetric cell division.  Notch also has an inhibitory effect on myocardial differentiation.
+*'''Cripto''' mediates Nodal signalling to allow for myocardial differentiation.
+{{Factor Links}}
+{{Footer}}
 [[Category:Heart ILP]] [[Category:Cardiovascular]] [[Category:Heart]] [[Category:Molecular]]