File:Lymph node cartoon 02.jpg: Difference between revisions

Cell Trafficking into and out of Lymph Nodes

Lymphocytes and dendritic cells (DCs) enter lymph nodes by different routes.

Lymphocytes

• Most lymphocytes migrating to lymph nodes enter from the peripheral blood.
• All leukocyte types are found in the arteries of lymph nodes.
• Only lymphocytes can interact with and extravasate through high endothelial venules (HEVs) to migrate into the lymph node parenchyma.
• T and B cells (lymphocytes) subsequently segregate into the T-cell zones and B-cell zones.

Dendritic cells

• Dendritic cells (DCs) with small numbers of lymphocytes enter lymph nodes through the afferent lymphatics.
• then accumulate in the vicinity of high endothelial venules.
• high endothelial venules are surrounded by fibroblastic reticular cells (FRCs)

Fibroblastic reticular cells

• (FRCs) form channels (FRC conduits) that project from the subcapsular sinus into the T-cell zone.
• Some chemokines produced extranodally might reach HEVs through the FRC conduit.

See also Lymph node - high endothelial venule cartoon.

Legend

• B - B-cell zones
• DC - dendritic cells
• FRC - fibroblastic reticular cells
• HEV - high endothelial venules

Lymph Node Cartoons: Detailed structure | Cartoon with Histology | Lymphocyte traffic | Simple structure | Simple node anatomy | Wiki node image | Internal structure | Mesenteric lymph node | Histology | Gallery | Lymph Node Development

Reference

<pubmed>15122201</pubmed>| Nat Rev Immunol.

Adapted by permission from Macmillan Publishers Ltd: Nat. Rev. Immunol.: 2004, 4(5);360-70, copyright (2004)

Licensee: Mark A Hill License Number: 2857291045727 Publication: Nature Reviews Immunology

Title: Lymphocyte trafficking across high endothelial venules: dogmas and enigmas Type Of Use: post on the internet

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