File:Lymph node cartoon 02.jpg: Difference between revisions

Revision as of 09:48, 28 February 2012

Lymphocytes and dendritic cells (DCs) enter lymph nodes by different routes.

Most lymphocytes migrating to lymph nodes enter from the peripheral blood.
Although various types of leukocyte are found in the arteries of lymph nodes, only lymphocytes can interact with and extravasate through high endothelial venules (HEVs) to migrate into the lymph-node parenchyma.
T and B cells (lymphocytes) subsequently segregate into the T-cell zones and B-cell zones.

DCs, together with small numbers of lymphocytes, enter lymph nodes through the afferent lymphatics.
then accumulate in the vicinity of high endothelial venules.
high endothelial venules are surrounded by fibroblastic reticular cells (FRCs)

(FRCs) form channels (FRC conduits) that project from the subcapsular sinus into the T-cell zone.
Some chemokines produced extranodally might reach HEVs through the FRC conduit.

<pubmed>15122201</pubmed>| Nat Rev Immunol.

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+==Cell Trafficking into and out of Lymph Nodes==
+Lymphocytes and dendritic cells (DCs) enter lymph nodes by different routes.
+===Lymphocytes===
+* Most lymphocytes migrating to lymph nodes enter from the peripheral blood.
+* Although various types of leukocyte are found in the arteries of lymph nodes, only lymphocytes can interact with and extravasate through high endothelial venules (HEVs) to migrate into the lymph-node parenchyma.
+* T and B cells (lymphocytes) subsequently segregate into the T-cell zones and B-cell zones.
+===Dendritic cells===
+* DCs, together with small numbers of lymphocytes, enter lymph nodes through the afferent lymphatics.
+* then accumulate in the vicinity of high endothelial venules.
+* high endothelial venules are surrounded by fibroblastic reticular cells (FRCs)
+===Fibroblastic reticular cells===
+* (FRCs) form channels (FRC conduits) that project from the subcapsular sinus into the T-cell zone.
+* Some chemokines produced extranodally might reach HEVs through the FRC conduit.
 {{Lymph node cartoons}}
+===Reference===
+<pubmed>15122201</pubmed>| [http://www.nature.com/nri/journal/v4/n5/full/nri1354.html Nat Rev Immunol.]