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Lymphocytes and dendritic cells (DCs) enter lymph nodes by different routes.  
Lymphocytes and dendritic cells (DCs) enter lymph nodes by different routes.  
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{|
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===Lymphocytes===
===Lymphocytes===
* Most lymphocytes migrating to lymph nodes enter from the peripheral blood.  
* Most lymphocytes migrating to lymph nodes enter from the peripheral blood.  
* All leukocyte types are found in the arteries of lymph nodes.
* All leukocyte types are found in the arteries of lymph nodes.
* Only lymphocytes can interact with and extravasate through high endothelial venules (HEVs) to migrate into the lymph node parenchyma.  
* Only lymphocytes can interact with and extravasate through high endothelial venules (HEVs) to migrate into the lymph node parenchyma.  
* T and B cells (lymphocytes) subsequently segregate into the T-cell zones and B-cell zones.
* T and B cells (lymphocytes) subsequently segregate into the T-cell zones and B-cell zones.
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===Legend===
===Legend===


* B -  B-cell zones
* '''B''' -  B-cell zones
* DC - dendritic cells
 
* FRC - fibroblastic reticular cells
* '''DC''' - dendritic cells
* HEV - high endothelial venues
 
* '''FRC''' - fibroblastic reticular cells
 
* '''HEV''' - high endothelial venues
|}
|}
===Dendritic cells===
===Dendritic cells===
* Dendritic cells (DCs) with small numbers of lymphocytes enter lymph nodes through the afferent lymphatics.  
* Dendritic cells (DCs) with small numbers of lymphocytes enter lymph nodes through the afferent lymphatics.  
* then accumulate in the vicinity of high endothelial venules.  
* then accumulate in the vicinity of high endothelial venules.  
* high endothelial venules are surrounded by fibroblastic reticular cells (FRCs)
* high endothelial venules are surrounded by fibroblastic reticular cells (FRCs)


===Fibroblastic reticular cells===  
===Fibroblastic reticular cells===  
* (FRCs) form channels (FRC conduits) that project from the subcapsular sinus into the T-cell zone.  
* (FRCs) form channels (FRC conduits) that project from the subcapsular sinus into the T-cell zone.  
* Some chemokines produced extranodally might reach HEVs through the FRC conduit.
* Some chemokines produced extranodally might reach HEVs through the FRC conduit.


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===Reference===
===Reference===


<pubmed>15122201</pubmed>| [http://www.nature.com/nri/journal/v4/n5/full/nri1354.html Nat Rev Immunol.]
{{#pmid:15122201}}
 
 


----
====Copyright====


Adapted by permission from Macmillan Publishers Ltd: Nat. Rev. Immunol.: 2004, 4(5);360-70, copyright (2004)
Adapted by permission from Macmillan Publishers Ltd: Nat. Rev. Immunol.: 2004, 4(5);360-70, copyright (2004)
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https://s100.copyright.com/CustomerAdmin/PLF.jsp?lID=2012021_1330385293727
https://s100.copyright.com/CustomerAdmin/PLF.jsp?lID=2012021_1330385293727


[[category:Blood]]
{{Footer}}
[[Category:Blood]][[Category:Immune]][[Category:Lymph Node]]

Latest revision as of 12:24, 12 February 2019

Cell Trafficking into and out of Lymph Nodes

Lymphocytes and dendritic cells (DCs) enter lymph nodes by different routes.

Lymphocytes

  • Most lymphocytes migrating to lymph nodes enter from the peripheral blood.
  • All leukocyte types are found in the arteries of lymph nodes.
  • Only lymphocytes can interact with and extravasate through high endothelial venules (HEVs) to migrate into the lymph node parenchyma.
  • T and B cells (lymphocytes) subsequently segregate into the T-cell zones and B-cell zones.

Legend

  • B - B-cell zones
  • DC - dendritic cells
  • FRC - fibroblastic reticular cells
  • HEV - high endothelial venues

Dendritic cells

  • Dendritic cells (DCs) with small numbers of lymphocytes enter lymph nodes through the afferent lymphatics.
  • then accumulate in the vicinity of high endothelial venules.
  • high endothelial venules are surrounded by fibroblastic reticular cells (FRCs)

Fibroblastic reticular cells

  • (FRCs) form channels (FRC conduits) that project from the subcapsular sinus into the T-cell zone.
  • Some chemokines produced extranodally might reach HEVs through the FRC conduit.


See also Lymph node - high endothelial venule cartoon.


Lymph Node Cartoons: Detailed structure | Cartoon with Histology | Lymphocyte traffic | Simple structure | Simple node anatomy | Wiki node image | Internal structure | Mesenteric lymph node | Histology | Gallery | Lymph Node Development

Reference

Miyasaka M & Tanaka T. (2004). Lymphocyte trafficking across high endothelial venules: dogmas and enigmas. Nat. Rev. Immunol. , 4, 360-70. PMID: 15122201 DOI.

Copyright

Adapted by permission from Macmillan Publishers Ltd: Nat. Rev. Immunol.: 2004, 4(5);360-70, copyright (2004)

Licensee: Mark A Hill License Number: 2857291045727 Publication: Nature Reviews Immunology

Title: Lymphocyte trafficking across high endothelial venules: dogmas and enigmas Type Of Use: post on the internet

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Cite this page: Hill, M.A. (2024, March 29) Embryology Lymph node cartoon 02.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Lymph_node_cartoon_02.jpg

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