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Lymphocytes and dendritic cells (DCs) enter lymph nodes by different routes. | Lymphocytes and dendritic cells (DCs) enter lymph nodes by different routes. | ||
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===Lymphocytes=== | ===Lymphocytes=== | ||
* Most lymphocytes migrating to lymph nodes enter from the peripheral blood. | * Most lymphocytes migrating to lymph nodes enter from the peripheral blood. | ||
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* Only lymphocytes can interact with and extravasate through high endothelial venules (HEVs) to migrate into the lymph node parenchyma. | * Only lymphocytes can interact with and extravasate through high endothelial venules (HEVs) to migrate into the lymph node parenchyma. | ||
* T and B cells (lymphocytes) subsequently segregate into the T-cell zones and B-cell zones. | * T and B cells (lymphocytes) subsequently segregate into the T-cell zones and B-cell zones. | ||
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===Legend=== | |||
* B - B-cell zones | |||
* DC - dendritic cells | |||
* FRC - fibroblastic reticular cells | |||
* HEV - high endothelial venues | |||
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===Dendritic cells=== | ===Dendritic cells=== | ||
* Dendritic cells (DCs) with small numbers of lymphocytes enter lymph nodes through the afferent lymphatics. | * Dendritic cells (DCs) with small numbers of lymphocytes enter lymph nodes through the afferent lymphatics. | ||
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See also [[:File:Lymph node - high endothelial venule.jpg|Lymph node - high endothelial venule cartoon]]. | See also [[:File:Lymph node - high endothelial venule.jpg|Lymph node - high endothelial venule cartoon]]. | ||
{{Lymph node cartoons}} | {{Lymph node cartoons}} |
Revision as of 09:33, 18 June 2014
Cell Trafficking into and out of Lymph Nodes
Lymphocytes and dendritic cells (DCs) enter lymph nodes by different routes.
Lymphocytes
|
Legend
|
Dendritic cells
- Dendritic cells (DCs) with small numbers of lymphocytes enter lymph nodes through the afferent lymphatics.
- then accumulate in the vicinity of high endothelial venules.
- high endothelial venules are surrounded by fibroblastic reticular cells (FRCs)
Fibroblastic reticular cells
- (FRCs) form channels (FRC conduits) that project from the subcapsular sinus into the T-cell zone.
- Some chemokines produced extranodally might reach HEVs through the FRC conduit.
See also Lymph node - high endothelial venule cartoon.
- Lymph Node Cartoons: Detailed structure | Cartoon with Histology | Lymphocyte traffic | Simple structure | Simple node anatomy | Wiki node image | Internal structure | Mesenteric lymph node | Histology | Gallery | Lymph Node Development
Reference
<pubmed>15122201</pubmed>| Nat Rev Immunol.
Adapted by permission from Macmillan Publishers Ltd: Nat. Rev. Immunol.: 2004, 4(5);360-70, copyright (2004)
Licensee: Mark A Hill License Number: 2857291045727 Publication: Nature Reviews Immunology
Title: Lymphocyte trafficking across high endothelial venules: dogmas and enigmas Type Of Use: post on the internet
https://s100.copyright.com/CustomerAdmin/PLF.jsp?lID=2012021_1330385293727
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