File:Liver histology 101.jpg

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Human Liver Histology

Liver histology showing detail of hepatocyte organisation and central vein. H&E

Liver Histology: Central vein (label) | Central vein (unlabel) | Portal triad 1 (label) | Portal triad 2 (label) | Portal triad (unlabel) | Hepatocytes (unlabel) | Hepatocytes polyploid (label) | Liver - reticular connective tissue (LP) | Liver - reticular connective tissue (HP) | Liver - fetal (HP) | Liver - fetal (HP) | Liver Development | GIT Histology


Liver histology showing detail of hepatocyte organization. H&E x20

Hepatocyte Structure

  • form about 80% of all liver cells
  • large polyhedral cells
  • large round centrally located nuclei
  • frequently polyploid[1]

Hepatocyte Function

  • glucose storage in the form of glycogen (SER)
  • vitamin A (possibly in specialized adipocytes), vitamin B12, folic acid and iron storage
  • lipid turnover and transport
  • plasmalipoproteins synthesis takes place almost exclusively in the liver (RER/SER)
  • plasma protein synthesis (albumin, α and β globulins, prothrombin, fibrinogen; RER)
  • metabolize/detoxify fat soluble compounds (drugs, insecticides; SER)
  • steroid hormone turnover
  • bile secretion (up to 1 liter per day from the whole liver)


  1. <pubmed>21778131</pubmed>

Original File name: Liverhum020HE.jpg

Links: Histology | Histology Stains | Blue Histology images copyright Lutz Slomianka 1998-2009. The literary and artistic works on the original Blue Histology website may be reproduced, adapted, published and distributed for non-commercial purposes. See also the page Histology Stains.

Cite this page: Hill, M.A. (2021, March 1) Embryology Liver histology 101.jpg. Retrieved from

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© Dr Mark Hill 2021, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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current15:50, 7 July 2011Thumbnail for version as of 15:50, 7 July 20111,280 × 1,024 (410 KB)S8600021 (talk | contribs)==Human Liver Histology== Showing central vein. H&E Original File name: Liverhum020HE.jpg {{Blue Histology}} Category:Human Category:Liver Category:Gastrointestinal Tract Category:Histology