File:Limb induction-initiation signal 02.jpg: Difference between revisions

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:[[Musculoskeletal System - Limb Development|'''Links''']]: [[:File:Limb induction-initiation signal 01.jpg|image - summary]] | [[:File:Limb induction-initiation signal 02.jpg|image - signal interaction]] | [[Developmental Signals - Retinoic acid|Retinoic acid]] | [[Developmental Signals - Tbx|Tbx]] | [[Developmental Signals - Fibroblast Growth Factor|FGF]] | [[Musculoskeletal System - Limb Development|Limb Development]]
:[[Musculoskeletal System - Limb Development|'''Links''']]: [[:File:Limb induction-initiation signal 01.jpg|image - summary]] | [[:File:Limb induction-initiation signal 02.jpg|image - signal interaction]] | [[Developmental Signals - Retinoic acid|Retinoic acid]] | [[Developmental Signals - Tbx|Tbx]] | [[Developmental Signals - Fibroblast Growth Factor|FGF]] | [[Musculoskeletal System - Limb Development|Limb Development]]


{{Tbx family collapsetable}}
===Reference===
===Reference===
<pubmed>26212321</pubmed>
<pubmed>26212321</pubmed>

Revision as of 15:43, 16 January 2018

Molecular Mechanisms of Limb Bud Formation

Figure from study that dshows the shared role of RA in forelimb and hindlimb and an evolutionarily conserved role of the b-catenin pathway in limb induction.

A - During limb induction, an axial signal is required for Raldh2 expression in the LPM, which produces retinoids acid (RA) locally. RA, b-catenin/TCF/LEF, and Hox genes act cooperatively to induce Tbx5 in the late real plate mesoderm (LPM).


B - Subsequently, RA from the somite functions cooperatively with Tbx5 to induce Fgf10 expression. Thus, RA and Tbx transcription factors act in a coherent feed-forward loop (D).


C and D - Fgf10 in limb bud mesenchyme induces Fgf8 expression (C) in the overlying ectoderm to establish an Fgf10-Fgf8 positive feedback loop required for outgrowth (D).


Links: image - summary | image - signal interaction | Retinoic acid | Tbx | FGF | Limb Development
Human TBX Family  
Table - Human Tbx Family
Approved
Symbol
Approved Name Previous Symbols Synonyms Chromosome
TBX1 T-box 1 VCF CATCH22 22q11.21
TBX2 T-box 2 17q23.2
TBX3 T-box 3 UMS "TBX3-ISO, XHL" 12q24.21
TBX4 T-box 4 17q23.2
TBX5 T-box 5 HOS 12q24.21
TBX6 T-box 6 16p11.2
TBX10 T-box 10 TBX7 TBX13 11q13.2
TBX15 T-box 15 TBX14 1p12
TBX18 T-box 18 6q14.3
TBX19 T-box 19 "dj747L4.1, TPIT" 1q24.2
TBX20 T-box 20 7p14.2
TBX21 T-box 21 "TBLYM, T-bet" 17q21.32
TBX22 T-box 22 "CPX, CLPA" Xq21.1
TBX23P T-box 23, pseudogene TBX23 1q25
TBR1 T-box, brain 1 2q24.2
EOMES eomesodermin TBR2 3p24.1
MGA MGA, MAX dimerization protein "KIAA0518, MAD5, MXD5, FLJ12634" 15q15
TBXT T-box transcription factor T T 6q27
    Links: Developmental Signals - Tbx | OMIM Tbx3 | HGNC | Bmp Family | Sox Family | Tbx Family

Reference

<pubmed>26212321</pubmed>


Copyright

Copyright © 2015 The Authors This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Figure 7. resized and labeled with PMID.


Cite this page: Hill, M.A. (2024, March 29) Embryology Limb induction-initiation signal 02.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Limb_induction-initiation_signal_02.jpg

What Links Here?
© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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current14:13, 13 September 2016Thumbnail for version as of 14:13, 13 September 20161,280 × 1,009 (124 KB)Z8600021 (talk | contribs)Figure 7. The Molecular Mechanisms of Limb Bud Formation (A) During limb induction, an axial signal is required for Raldh2 expression in the LPM, which produces RA locally. RA, b-catenin/TCF/LEF, and Hox genes act cooperatively to induce Tbx5 in the LP...

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