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'''B''' - Subsequently, RA from the somite functions cooperatively with Tbx5 to induce Fgf10 expression. Thus, RA and Tbx transcription factors act in a coherent feed-forward loop (D). | '''B''' - Subsequently, RA from the somite functions cooperatively with Tbx5 to induce Fgf10 expression. Thus, RA and Tbx transcription factors act in a coherent feed-forward loop (D). | ||
'''C''' and '''D''' - Fgf10 in limb bud mesenchyme induces Fgf8 expression (C) in the overlying ectoderm to establish an Fgf10-Fgf8 positive feedback loop required for outgrowth (D). | |||
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[[Category:Limb]][[Category:Cartoon]][ | [[Category:Limb]][[Category:Cartoon]][[Category:FGF]] | ||
Revision as of 13:17, 13 September 2016
Molecular Mechanisms of Limb Bud Formation
Study demonstrates the shared role of RA in forelimb and hindlimb and an evolutionarily conserved role of the b-catenin pathway in limb induction.
A - During limb induction, an axial signal is required for Raldh2 expression in the LPM, which produces retinoids acid (RA) locally. RA, b-catenin/TCF/LEF, and Hox genes act cooperatively to induce Tbx5 in the late real plate mesoderm (LPM).
B - Subsequently, RA from the somite functions cooperatively with Tbx5 to induce Fgf10 expression. Thus, RA and Tbx transcription factors act in a coherent feed-forward loop (D).
C and D - Fgf10 in limb bud mesenchyme induces Fgf8 expression (C) in the overlying ectoderm to establish an Fgf10-Fgf8 positive feedback loop required for outgrowth (D).
- Links: image - summary | image - signal interaction | Retinoic acid | Tbx
Reference
<pubmed>26212321</pubmed>
Copyright
Copyright © 2015 The Authors This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Figure 7. resized and labeled with PMID.
Cite this page: Hill, M.A. (2024, April 25) Embryology Limb induction-initiation signal 02.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Limb_induction-initiation_signal_02.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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| current | 13:13, 13 September 2016 |  | 1,280 × 1,009 (124 KB) | Z8600021 (talk | contribs) | Figure 7. The Molecular Mechanisms of Limb Bud Formation (A) During limb induction, an axial signal is required for Raldh2 expression in the LPM, which produces RA locally. RA, b-catenin/TCF/LEF, and Hox genes act cooperatively to induce Tbx5 in the LP... |
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