https://embryology.med.unsw.edu.au/embryology/index.php?title=File:Isthmic_Organiser.png&feed=atom&action=historyFile:Isthmic Organiser.png - Revision history2024-03-29T04:55:47ZRevision history for this page on the wikiMediaWiki 1.39.6https://embryology.med.unsw.edu.au/embryology/index.php?title=File:Isthmic_Organiser.png&diff=315410&oldid=prevZ5018156 at 06:51, 25 October 20172017-10-25T06:51:37Z<p></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 17:51, 25 October 2017</td>
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<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">=Isthmic Organiser=</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>The role of the Isthmic Organiser. "The establishment of gene expression domains along the anterior-posterior axis helps to segment the developing brain into the forebrain, midbrain (MB), hindbrain (HB) and spinal cord (SC). The Isthmic Organizer (IsO; shown in yellow) forms at the boundary of the posterior midbrain and anterior hindbrain: the IsO secretes Fgf8 and other growth factors, and is essential for defining the regions of the neural plate that will become the posterior midbrain (shown in blue) and the cerebellum (CB; green). The homeobox genes Otx2 and Gbx2 are involved in the formation of the IsO and in regulating the expression of Fgf8 by the IsO. Mutations in the CHARGE syndrome gene, CHD7, can alter Otx2, Gbx2 and Fgf8 expression, resulting in underdevelopment of a region of the cerebellum called the vermis (right)."<ref><pubmed>3870571</pubmed></ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>The role of the Isthmic Organiser. "The establishment of gene expression domains along the anterior-posterior axis helps to segment the developing brain into the forebrain, midbrain (MB), hindbrain (HB) and spinal cord (SC). The Isthmic Organizer (IsO; shown in yellow) forms at the boundary of the posterior midbrain and anterior hindbrain: the IsO secretes Fgf8 and other growth factors, and is essential for defining the regions of the neural plate that will become the posterior midbrain (shown in blue) and the cerebellum (CB; green). The homeobox genes Otx2 and Gbx2 are involved in the formation of the IsO and in regulating the expression of Fgf8 by the IsO. Mutations in the CHARGE syndrome gene, CHD7, can alter Otx2, Gbx2 and Fgf8 expression, resulting in underdevelopment of a region of the cerebellum called the vermis (right)."<ref><pubmed>3870571</pubmed></ref></div></td></tr>
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</table>Z5018156https://embryology.med.unsw.edu.au/embryology/index.php?title=File:Isthmic_Organiser.png&diff=314206&oldid=prevZ5076158: /* Reference */2017-10-23T10:49:51Z<p><span dir="auto"><span class="autocomment">Reference</span></span></p>
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</table>Z5076158https://embryology.med.unsw.edu.au/embryology/index.php?title=File:Isthmic_Organiser.png&diff=314204&oldid=prevZ5076158: The role of the Isthmic Organiser. "The establishment of gene expression domains along the anterior-posterior axis helps to segment the developing brain into the forebrain, midbrain (MB), hindbrain (HB) and spinal cord (SC). The Isthmic Organizer (IsO;...2017-10-23T10:49:34Z<p>The role of the Isthmic Organiser. "The establishment of gene expression domains along the anterior-posterior axis helps to segment the developing brain into the forebrain, midbrain (MB), hindbrain (HB) and spinal cord (SC). The Isthmic Organizer (IsO;...</p>
<p><b>New page</b></p><div>The role of the Isthmic Organiser. "The establishment of gene expression domains along the anterior-posterior axis helps to segment the developing brain into the forebrain, midbrain (MB), hindbrain (HB) and spinal cord (SC). The Isthmic Organizer (IsO; shown in yellow) forms at the boundary of the posterior midbrain and anterior hindbrain: the IsO secretes Fgf8 and other growth factors, and is essential for defining the regions of the neural plate that will become the posterior midbrain (shown in blue) and the cerebellum (CB; green). The homeobox genes Otx2 and Gbx2 are involved in the formation of the IsO and in regulating the expression of Fgf8 by the IsO. Mutations in the CHARGE syndrome gene, CHD7, can alter Otx2, Gbx2 and Fgf8 expression, resulting in underdevelopment of a region of the cerebellum called the vermis (right)."<ref><pubmed>3870571</pubmed></ref><br />
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