File:Isthmic Organiser.png: Difference between revisions

From Embryology
(The role of the Isthmic Organiser. "The establishment of gene expression domains along the anterior-posterior axis helps to segment the developing brain into the forebrain, midbrain (MB), hindbrain (HB) and spinal cord (SC). The Isthmic Organizer (IsO;...)
 
Line 2: Line 2:


==Reference==
==Reference==
</references>
<references/>


===Copyright===
===Copyright===

Revision as of 21:49, 23 October 2017

The role of the Isthmic Organiser. "The establishment of gene expression domains along the anterior-posterior axis helps to segment the developing brain into the forebrain, midbrain (MB), hindbrain (HB) and spinal cord (SC). The Isthmic Organizer (IsO; shown in yellow) forms at the boundary of the posterior midbrain and anterior hindbrain: the IsO secretes Fgf8 and other growth factors, and is essential for defining the regions of the neural plate that will become the posterior midbrain (shown in blue) and the cerebellum (CB; green). The homeobox genes Otx2 and Gbx2 are involved in the formation of the IsO and in regulating the expression of Fgf8 by the IsO. Mutations in the CHARGE syndrome gene, CHD7, can alter Otx2, Gbx2 and Fgf8 expression, resulting in underdevelopment of a region of the cerebellum called the vermis (right)."[1]

Reference

  1. <pubmed>3870571</pubmed>

Copyright

This file is licensed under the https://creativecommons.org/licenses/by-sa/3.0/deed.en Unported license. Subject to disclaimers. You are free: to share – to copy, distribute and transmit the work, to remix – to adapt the work. Under the following conditions: attribution – You must attribute the work in the manner specified by the author or licensor (but not in any way that suggests that they endorse you or your use of the work). share alike – If you alter, transform, or build upon this work, you may distribute the resulting work only under the same or similar license to this one.


Note - This image was originally uploaded as part of an undergraduate science student project and may contain inaccuracies in either description or acknowledgements. Students have been advised in writing concerning the reuse of content and may accidentally have misunderstood the original terms of use. If image reuse on this non-commercial educational site infringes your existing copyright, please contact the site editor for immediate removal.

File history

Click on a date/time to view the file as it appeared at that time.

Date/TimeThumbnailDimensionsUserComment
current21:49, 23 October 2017Thumbnail for version as of 21:49, 23 October 20171,235 × 362 (272 KB)Z5076158 (talk | contribs)The role of the Isthmic Organiser. "The establishment of gene expression domains along the anterior-posterior axis helps to segment the developing brain into the forebrain, midbrain (MB), hindbrain (HB) and spinal cord (SC). The Isthmic Organizer (IsO;...

The following 2 pages use this file:

Metadata