File:Integumentary touch dome model 01.jpg
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Proposed model of the developmental signaling requirements for TD MC production
touch dome (TD) is a specialized epidermal sensory structure composed of K8+ Merkel cells (MCs)
(left) Model of the signaling cascade that regulates the development of TD MCs and their adjacent guard hair follicle, along with experimental interventions that disrupted or rescued the developmental processes. (right) Graphical representation of the sequential signaling mechanisms that drive TD MC specification in embryonic mouse skin. TD MC specification requires mesenchymal Wnt signaling which allows Eda signaling to Edar in the developing primary hair placodes and subsequent Shh signaling from the primary hair placodes/germs to adjacent ectoderm containing the TD anlages. Square cells, surface ectoderm. Trapezoidal cells, hair placode/germ cells. Oval cells, periderm.
PMID 27414798
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Fig 7. doi:10.1371/journal.pgen.1006150.g007
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| current | 14:34, 12 August 2017 | | 1,280 × 724 (144 KB) | Z8600021 (talk | contribs) | ==Proposed model of the developmental signaling requirements for TD MC production== touch dome (TD) is a specialized epidermal sensory structure composed of K8+ Merkel cells (MCs) (left) Model of the signaling cascade that regulates the development o... |
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