File:Implantation LIF.jpg
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Uterine Leukemia Inhibitory Factor (LIF) Expression
a - At day 4 of pregnancy, oestrogen E2 induces LIF expression in the endometrial glands, leading to LIF secretion into the uterine lumen. There, LIF binds to its receptors on the surface of epithelial cells.
b - This makes the uterus receptive to the blastocyst, which implants by day 5 of pregnancy. Hu et al.2 find that LIF expression in the endometrial glands also depends on the regulatory activity of p53. In the absence of p53, insufficient LIF is produced, the uterus does not become adequately receptive, and fewer blastocysts implant.
See also
- http://www.nature.com/nature/journal/v450/n7170/full/nature05993.html
- http://www.nature.com/nrg/journal/v7/n3/full/nrg1808.html
Reference
<pubmed>18046411</pubmed>
Image source: News and Views - Stewart, CL Nature 450, 619 (29 November 2007) by permission from Macmillan Publishers Ltd (copyright 2007) p53 regulates maternal reproduction through LIF. Nature. 2007 Nov 29;450(7170):721-4.)
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 12:46, 7 November 2009 | | 800 × 325 (48 KB) | S8600021 (talk | contribs) | a At day 4 of pregnancy, oestrogen E2 induces LIF expression in the endometrial glands, leading to LIF secretion into the uterine lumen. There, LIF binds to its receptors on the surface of epithelial cells. bThis makes the uterus receptive to the blasto |
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