File:Implantation LIF.jpg: Difference between revisions
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==Uterine Leukemia Inhibitory Factor (LIF) Expression== | ==Uterine Leukemia Inhibitory Factor (LIF) Expression== | ||
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| | | col width=400px valign=top|'''a''' - Day 4 of pregnancy, oestrogen E2 induces LIF expression in the endometrial glands, leading to LIF secretion into the uterine lumen. | ||
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There, LIF binds to its receptors on the surface of epithelial cells. | |||
| col width=400px|'''b'''- Day 5 uterus receptive to the blastocyst, which implants by day 5 of pregnancy. | |||
Hu et al. find that LIF expression in the endometrial glands also depends on the regulatory activity of p53. In the absence of p53, insufficient LIF is produced, the uterus does not become adequately receptive, and fewer blastocysts implant. | |||
|} | |} | ||
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===Reference=== | ===Reference=== | ||
{{#pmid:18046411}} | |||
http://www.nature.com/nrg/journal/v7/n3/full/nrg1808.html | http://www.nature.com/nrg/journal/v7/n3/full/nrg1808.html | ||
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Image source: News and Views - Stewart, CL Nature 450, 619 (29 November 2007) by permission from Macmillan Publishers Ltd (copyright 2007) p53 regulates maternal reproduction through LIF. Nature. 2007 Nov 29;450(7170):721-4.) | Image source: News and Views - Stewart, CL Nature 450, 619 (29 November 2007) by permission from Macmillan Publishers Ltd (copyright 2007) p53 regulates maternal reproduction through LIF. Nature. 2007 Nov 29;450(7170):721-4.) | ||
{{Footer}} | |||
[[Category:Uterus]] [[Category:Implantation]] [[Category:Cartoon]] [[Category:Developmental Signal]] [[Category:Mouse]] [[Category:Molecular]] | [[Category:Uterus]] [[Category:Implantation]] [[Category:Cartoon]] [[Category:Developmental Signal]] [[Category:Mouse]] [[Category:Molecular]] |
Latest revision as of 15:52, 22 March 2018
Uterine Leukemia Inhibitory Factor (LIF) Expression
a - Day 4 of pregnancy, oestrogen E2 induces LIF expression in the endometrial glands, leading to LIF secretion into the uterine lumen.
There, LIF binds to its receptors on the surface of epithelial cells. |
b- Day 5 uterus receptive to the blastocyst, which implants by day 5 of pregnancy.
Hu et al. find that LIF expression in the endometrial glands also depends on the regulatory activity of p53. In the absence of p53, insufficient LIF is produced, the uterus does not become adequately receptive, and fewer blastocysts implant. |
- Links: Implantation
Reference
Hu W, Feng Z, Teresky AK & Levine AJ. (2007). p53 regulates maternal reproduction through LIF. Nature , 450, 721-4. PMID: 18046411 DOI.
http://www.nature.com/nrg/journal/v7/n3/full/nrg1808.html
Copyright
Image source: News and Views - Stewart, CL Nature 450, 619 (29 November 2007) by permission from Macmillan Publishers Ltd (copyright 2007) p53 regulates maternal reproduction through LIF. Nature. 2007 Nov 29;450(7170):721-4.)
Cite this page: Hill, M.A. (2024, April 25) Embryology Implantation LIF.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Implantation_LIF.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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