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Hypothalamus Development Gene Interaction Model

Summary of potential regulatory interaction model of gene regulation for neurogenesis in the hypothalamus revealed by in silico analysis and literature.

A model of interaction between the negative regulators HES5 and HEY1 and the positive regulators ASCL1 and NHLH1 based on the literature and present data.

  • Activations - identified with a red arrow
  • Repressions - identified with a green barred line.
  • Purple arrow - activation of NOTCH receptor by its ligand DLL1.

(Bertrand, 2002; Gohkle, 2008, Castro, 2011, de la Pompa 1997, and paper data).

Links: Hypothalamus | Notch


Ratié L, Ware M, Barloy-Hubler F, Romé H, Gicquel I, Dubourg C, David V & Dupé V. (2013). Novel genes upregulated when NOTCH signalling is disrupted during hypothalamic development. Neural Dev , 8, 25. PMID: 24360028 DOI.


© 2013 Ratié et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Ratié et al. Neural Development 2013 8:25 doi:10.1186/1749-8104-8-25


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