File:Human-critical periods of development.jpg

From Embryology

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Human-critical periods of development

The table below identifies approximate windows of time, "critical periods", that following exposure to teratogens can lead to developmental abnormalities (anomalies, congenital).

In general, the effects for each system are more severe (major anomalies) in the embryonic period during organogenesis in the first trimester.

Later teratogen exposure are less severe (minor anomalies) in the fetal period during continued growth and differentiation in the second and third trimester.

This figure is also available as a formatted table.


Dark Orange = major abnormality | Light Orange = minor abnormality


Links: Table version | Human Abnormal Development

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