File:Hoxa gene expression in limb bud 01.jpg

Hoxa gene expression in limb buds

Expression of Hoxa4, Hoxa9, Hoxa10, Hoxa11, Hoxa11 antisense (Hoxa11as), and Hoxa13 in E12.5 limb buds. The Hoxa11as transcript originates from a promoter within the intron of Hoxa11 (upper panel) and is expressed like Hoxa13.

Both Hoxa13 and the Hoxa11 antisense transcript (Hoxa11as) accumulate only in the distal, presumptive digit domain and in the future wrist. A noticeable difference with Hoxd genes was observed, however, as Hoxa11 transcripts are absent from this distal domain, while present in the proximal territory, suggesting that Hoxa11 may escape the distal regulation imposed on the Hoxa9 to Hoxa13 genes, unlike in the case of HoxD, where Hoxd9 to Hoxd13 genes are coregulated in digits.

| Category:Hox

Reference

<pubmed>24465181</pubmed>| PLoS Biol.

Copyright

© 2014 Woltering et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Figure 2. Journal.pbio.1001773.g002.jpg Panel A cropped from fig 1 and resized and relabeled.