File:Heart Defects.png: Difference between revisions

Fig. 26.2 Cellular interaction of the second heart field (SHF) and cardiac neural crest (CNC) for the outflow tract (OFT) development and diseases. Progenitor cells derived from the SHF and the CNC give rise to the OFT myocardium and septum, respectively. TBX1 is exclusively expressed in the SHF cells. TBX1 deletion in 22q11DS may affect not only the SHF cells but also the interaction between the SHF cells and CNC, resulting in OFT defects ranging from TOF, which is characterized by malalignment of the OFT septum, to PTA, which results from aplasia of the OFT septum. GATA6-SEMA3C (ligand)-PLXNA2 (receptor) pathway also plays a role in interaction between the SHF and CNC during the OFT development (Modified from [36])

Reference

The Author(s) 2016T. Nakanishi et al. (eds.),Etiology and Morphogenesis of Congenital Heart Disease,DOI 10.1007/978-4-431-54628-3_26

Copyright

Available via license: CC BY-NC 2.5

LicenseCC BY-NC 2.5

https://creativecommons.org/licenses/by-nc/2.5/

Note - This image was originally uploaded as part of an undergraduate science student 2018 project and may contain inaccuracies in either description or acknowledgements. Students have been advised in writing concerning the reuse of content and may accidentally have misunderstood the original terms of use. If image reuse on this non-commercial educational site infringes your existing copyright, please contact the site editor for immediate removal.

z5229281