File:Fetal Colonic Inury Model Diagram.png: Difference between revisions
(Diagram of Fetal Injury Colonic Model as seen in study: PMID: 24139758) |
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==Fetal Intestine Transplantat Injury Model== | |||
This is a hand drawn digram of the process described in the study by R. Fordham et. al <ref name="PMID3858813"><pubmed>3858813</pubmed></ref>. The left hand side of the diagram shows the immature cells of the human body (induced pluripotent cells shown in red and the immature cells of the intestine shown down the bottom in the red and blue) that can form spondin independent Fetal Enterospheres (FEnS). This is important as in this study using models of both fetal mouse and humans it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers<ref name="PMID3858813"><pubmed>3858813</pubmed></ref>. The right hand side of the diagram shows the mature intestine cells. From differing techniques it was found that the FEnS were able to form regeneration of an intestinal injury while in vitro maturation of the immature intestinal cells merely formed the spondin dependant organoids. | |||
==References== | |||
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Revision as of 17:45, 23 October 2014
Fetal Intestine Transplantat Injury Model
This is a hand drawn digram of the process described in the study by R. Fordham et. al [1]. The left hand side of the diagram shows the immature cells of the human body (induced pluripotent cells shown in red and the immature cells of the intestine shown down the bottom in the red and blue) that can form spondin independent Fetal Enterospheres (FEnS). This is important as in this study using models of both fetal mouse and humans it was found that FEnS contribute to the regeneration of colonic epithelium by the formation of drypt-like epithelial structures that expressed region-specific differentiation markers[1]. The right hand side of the diagram shows the mature intestine cells. From differing techniques it was found that the FEnS were able to form regeneration of an intestinal injury while in vitro maturation of the immature intestinal cells merely formed the spondin dependant organoids.
References
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