File:FGF signalling pathway.jpg

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FGF Signalling Pathway

Description

Summary of the FGFR signalling pathway. The FGFR signalling pathway is capable of altering DNA expression through the downstream signalling of PI3K, RAS and IP3 pathways. This will stimulate the binding of Elk1 and ATF2 directly to DNA within the nucleus of cells therefore altering gene expression. Abbreviations: ATF2 (Activating transcription factor 2), Ca2+(calcium ions), CDC42(Cell division control protein 42 homolog), DAG(diacylglycerol), Elk1( ETS-DOMAIN PROTEIN 1), ERK1/2(Extracellular Signal-Regulated Kinases 1 and 2), FRS2(Fibroblast growth factor receptor substrate 2), GAP(GTPase-Activating Proteins), GDP ( guanosine diphosphate), GRB2(Growth factor receptor-bound protein 2 ), GTP(guanosine triphosphate), IP3(Inositol trisphosphate or inositol 1,4,5-trisphosphate), JNK(c-Jun N-terminal kinases), MEKK(MAPK/Erk kinase kinase), MKK3/6(Dual specificity mitogen-activated protein kinase 3 and 6), RA1 (Retinoic acid 1), Rac1 (Ras-Related C3 Botulinum Toxin Substrate 1), PLC(Phospholipase C), PLD(Phospholipase D), SOS(Son of Sevenless)

References

Image was drawn from the signalling pathway presented in: [1]


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  1. <pubmed>27458533</pubmed>

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current15:52, 28 September 2016Thumbnail for version as of 15:52, 28 September 20163,507 × 2,550 (1.11 MB)Z5015544 (talk | contribs)<b> Summary of the FGFR signalling pathway.</b> The FGFR signalling pathway is capable of altering DNA expression through the downstream signalling of PI3K, RAS and IP3 pathways. This will stimulate the binding of Elk1 and ATF2 directly to DNA within t...

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