File:Endochondral bone cartoon.jpg

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Endochondral Bone Development

Longitudinal views depicting key steps of endochondral bone formation in mouse limbs.

a - Prx1+ progenitors from lateral plate mesoderm proliferate to populate the emerging limb bud.
b - Cells nearest the centre undergo mesenchymal condensation, express Col2a1 as they enter a chondrogenic differentiation program, and deposit a cartilage template.
c to d - Differentiating cells upregulate Col10a1 as they become hypertrophic, which triggers local formation of a bone collar and vascularization of the cartilage template. Invading blood vessels deliver an influx of haematopoietic cells that give rise to osteoclasts which excavate the cartilage template, and Osx1+ osteoblast progenitors and other blood cell types that populate the newly formed marrow cavity.
d - A longitudinal growth axis is established when vascularization and osteoclast-mediated resorption bisect the presumptive skeletal element, producing two growth plates with opposing directionality. A perpendicular growth axis is driven by periosteal osteoblasts and allows the bone to grow in width.
e - Within the remodelled cartilage template, bone-forming osteoblasts are derived from Osx1+ cells arriving with the invading vasculature, as well as hypertrophic Col10a1+ chondroctyes that transdifferentiate as they exit the growth plate into the marrow cavity. As bones grow in length and width, a second wave of vascularization forms the secondary ossification centres.
f - Mature endochondral bone.

Historic Embryology - Musculoskeletal
1853 Bone \| 1885 Sphenoid \| 1902 - Pubo-femoral Region \| Spinal Column and Back \| Body Segmentation \| Cranium \| Body Wall, Ribs, and Sternum \| Limbs \| 1901 - Limbs \| 1902 - Arm Development \| 1906 Human Embryo Ossification \| 1906 Lower limb Nerves and Muscle \| 1907 - Muscular System \| Skeleton and Limbs \| 1908 Vertebra \| 1908 Cervical Vertebra \| 1909 Mandible \| 1910 - Skeleton and Connective Tissues \| Muscular System \| Coelom and Diaphragm \| 1913 Clavicle \| 1920 Clavicle \| 1921 - External body form \| Connective tissues and skeletal \| Muscular \| Diaphragm \| 1929 Rat Somite \| 1932 Pelvis \| 1940 Synovial Joints \| 1943 Human Embryonic, Fetal and Circumnatal Skeleton \| 1947 Joints \| 1949 Cartilage and Bone \| 1957 Chondrification Hands and Feet \| 1968 Knee

Mouse Development

Reference

Salazar VS, Gamer LW & Rosen V. (2016). BMP signalling in skeletal development, disease and repair. Nat Rev Endocrinol , 12, 203-21. PMID: 26893264 DOI.

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Order Details Licensee: Mark A Hill License Date: Sep 11, 2016 License Number: 3946190772930 Publication: Nature Reviews Endocrinology Title: BMP signalling in skeletal development, disease and repair Type Of Use: post on a website

Cite this page: Hill, M.A. (2024, April 23) Embryology Endochondral bone cartoon.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Endochondral_bone_cartoon.jpg

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	Date/Time	Thumbnail	Dimensions	User	Comment
current	10:20, 12 September 2016		946 × 513 (127 KB)	Z8600021 (talk \| contribs)	==Endochondral Bone Development== Longitudinal views depicting key steps of endochondral bone formation in mouse limbs. a \| Prx1+ progenitors from lateral plate mesoderm proliferate to populate the emerging limb bud. b \| Cells nearest the centre under...

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