File:Endochondral bone cartoon.jpg: Difference between revisions

Endochondral Bone Development

Longitudinal views depicting key steps of endochondral bone formation in mouse limbs. a | Prx1+ progenitors from lateral plate mesoderm proliferate to populate the emerging limb bud. b | Cells nearest the centre undergo mesenchymal condensation, express Col2a1 as they enter a chondrogenic differentiation program, and deposit a cartilage template. c | to d | Differentiating cells upregulate Col10a1 as they become hypertrophic, which triggers local formation of a bone collar and vascularization of the cartilage template. Invading blood vessels deliver an influx of haematopoietic cells that give rise to osteoclasts which excavate the cartilage template, and Osx1+ osteoblast progenitors and other blood cell types that populate the newly formed marrow cavity. d | A longitudinal growth axis is established when vascularization and osteoclast-mediated resorption bisect the presumptive skeletal element, producing two growth plates with opposing directionality. A perpendicular growth axis is driven by periosteal osteoblasts and allows the bone to grow in width. e | Within the remodelled cartilage template, bone-forming osteoblasts are derived from Osx1+ cells arriving with the invading vasculature, as well as hypertrophic Col10a1+ chondroctyes that transdifferentiate as they exit the growth plate into the marrow cavity. As bones grow in length and width, a second wave of vascularization forms the secondary ossification centres. f | Mature endochondral bone.

Reference

<pubmed>26893264</pubmed>

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Order Details Licensee: Mark A Hill License Date: Sep 11, 2016 License Number: 3946190772930 Publication: Nature Reviews Endocrinology Title: BMP signalling in skeletal development, disease and repair Type Of Use: post on a website

Cite this page: Hill, M.A. (2024, April 18) Embryology Endochondral bone cartoon.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Endochondral_bone_cartoon.jpg

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