File:Embryo left-right asymmetry pathway.jpg

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Revision as of 13:50, 16 January 2013 by Z8600021 (talk | contribs) (Reference)
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Embryo Left-Right Asymmetry Pathway

(a) An 8.25-day mouse embryo showing asymmetric Nodal expression (in blue) at the node as well as in the left, but not the right, lateral plate, and asymmetric Cerl2 expression in purple.

(b) A higher magnification of the node. The central pit of the node contains motile cilia (not shown) that drive a leftwards nodal flow (indicated by arrows). Surrounding the node are the node crown cells; these express Nodal (represented by blue dots) in an asymmetric fashion, with expression stronger on the left than on the right. An asymmetric calcium signal (represented by red stars) is also stronger on the left than the right. Downstream of nodal flow and asymmetric gene expression at the node, a 'leftness' signal is communicated several cell diameters to the left lateral plate mesoderm (LPM). Here it activates the Nodal signaling cascade, ultimately resulting in left-side-specific Pitx2 expression and asymmetric morphogenesis. The primary axes are shown: anterior-posterior (A-P); dorsal-ventral (D-V); left-right (L-R).


Reference

Norris BMC Biology 2012 10:102 doi:10.1186/1741-7007-10-102

http://www.biomedcentral.com/1741-7007/10/102

Copyright

© 2012 Norris; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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current13:48, 16 January 2013Thumbnail for version as of 13:48, 16 January 2013800 × 458 (46 KB)Z8600021 (talk | contribs)==Embryo Left-Right Asymmetry Pathway== (a) An 8.25-day mouse embryo showing asymmetric Nodal expression (in blue) at the node as well as in the left, but not the right, lateral plate, and asymmetric Cerl2 expression in purple. (b) A higher magnificati
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