Difference between revisions of "File:Embryo left-right asymmetry pathway.jpg"

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==Embryo Left-Right Asymmetry Pathway==
 
==Embryo Left-Right Asymmetry Pathway==
  
(a) An 8.25-day mouse embryo showing asymmetric Nodal expression (in blue) at the node as well as in the left, but not the right, lateral plate, and asymmetric Cerl2 expression in purple.  
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* '''a''' - An 8.25-day mouse embryo showing asymmetric Nodal expression (in blue) at the node as well as in the left, but not the right, lateral plate, and asymmetric Cerl2 expression in purple.
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* '''b''' - A higher magnification of the node. The central pit of the node contains motile cilia (not shown) that drive a leftwards nodal flow (indicated by arrows). Surrounding the node are the node crown cells; these express Nodal (represented by blue dots) in an asymmetric fashion, with expression stronger on the left than on the right. An asymmetric calcium signal (represented by red stars) is also stronger on the left than the right. Downstream of nodal flow and asymmetric gene expression at the node, a 'leftness' signal is communicated several cell diameters to the left lateral plate mesoderm (LPM). Here it activates the Nodal signaling cascade, ultimately resulting in left-side-specific Pitx2 expression and asymmetric morphogenesis.  
  
(b) A higher magnification of the node. The central pit of the node contains motile cilia (not shown) that drive a leftwards nodal flow (indicated by arrows). Surrounding the node are the node crown cells; these express Nodal (represented by blue dots) in an asymmetric fashion, with expression stronger on the left than on the right. An asymmetric calcium signal (represented by red stars) is also stronger on the left than the right. Downstream of nodal flow and asymmetric gene expression at the node, a 'leftness' signal is communicated several cell diameters to the left lateral plate mesoderm (LPM). Here it activates the Nodal signaling cascade, ultimately resulting in left-side-specific Pitx2 expression and asymmetric morphogenesis. The primary axes are shown: anterior-posterior (A-P); dorsal-ventral (D-V); left-right (L-R).
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The primary axes are shown: anterior-posterior (A-P); dorsal-ventral (D-V); left-right (L-R).
  
  
===Reference===
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:'''Links:''' [[Developmental Mechanisms]]
<pubmed>23256866</pubmed>| [http://www.biomedcentral.com/1741-7007/10/102 BMC Biology]
 
  
  
Norris BMC Biology 2012 10:102  doi:10.1186/1741-7007-10-102
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{{Mechanism Links}}
  
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{{Molecular Links}}
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{{Factor Links}}
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===Reference===
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<pubmed>23256866</pubmed>| [http://www.biomedcentral.com/1741-7007/10/102 BMC Biology]
  
 
====Copyright====
 
====Copyright====
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© 2012 Norris; licensee BioMed Central Ltd.  
 
© 2012 Norris; licensee BioMed Central Ltd.  
 
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Norris BMC Biology 2012 10:102  doi:10.1186/1741-7007-10-102
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{{Footer}}
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[[Category:Cartoon]][[Category:Molecular]][[Category:Week 3]][[Category:Gastrulation]][[Category:Mesoderm]]
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[[Category:Mouse E8.5]]

Latest revision as of 17:30, 12 August 2016

Embryo Left-Right Asymmetry Pathway

  • a - An 8.25-day mouse embryo showing asymmetric Nodal expression (in blue) at the node as well as in the left, but not the right, lateral plate, and asymmetric Cerl2 expression in purple.
  • b - A higher magnification of the node. The central pit of the node contains motile cilia (not shown) that drive a leftwards nodal flow (indicated by arrows). Surrounding the node are the node crown cells; these express Nodal (represented by blue dots) in an asymmetric fashion, with expression stronger on the left than on the right. An asymmetric calcium signal (represented by red stars) is also stronger on the left than the right. Downstream of nodal flow and asymmetric gene expression at the node, a 'leftness' signal is communicated several cell diameters to the left lateral plate mesoderm (LPM). Here it activates the Nodal signaling cascade, ultimately resulting in left-side-specific Pitx2 expression and asymmetric morphogenesis.

The primary axes are shown: anterior-posterior (A-P); dorsal-ventral (D-V); left-right (L-R).


Links: Developmental Mechanisms


Mechanism Links: mitosis | cell migration | epithelial invagination | epithelial mesenchymal transition | mesenchymal epithelial transition | epithelial mesenchymal interaction | morphodynamics | tube formation | apoptosis | autophagy | axes formation | time | molecular
Molecular Links: molecular | genetics | epigenetics | mitosis | meiosis | X Inactivation | Signaling | Factors | Mouse Knockout | microRNA | Mechanisms | Developmental Enhancers | Protein | Genetic Abnormal | Category:Molecular
Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular

Reference

<pubmed>23256866</pubmed>| BMC Biology

Copyright

© 2012 Norris; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Norris BMC Biology 2012 10:102 doi:10.1186/1741-7007-10-102


Cite this page: Hill, M.A. (2019, October 23) Embryology Embryo left-right asymmetry pathway.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Embryo_left-right_asymmetry_pathway.jpg

What Links Here?
© Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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current14:48, 16 January 2013Thumbnail for version as of 14:48, 16 January 2013800 × 458 (46 KB)Z8600021 (talk | contribs)==Embryo Left-Right Asymmetry Pathway== (a) An 8.25-day mouse embryo showing asymmetric Nodal expression (in blue) at the node as well as in the left, but not the right, lateral plate, and asymmetric Cerl2 expression in purple. (b) A higher magnificati
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