File:Electroencephalography of Angelman Syndrome.jpg
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Electroencephalography_of_Angelman_Syndrome.jpg (440 × 207 pixels, file size: 33 KB, MIME type: image/jpeg)
Electroencephalography of Angelman Syndrome
Electroencephalography (EEG) showing Normal and abnormal EEGs in both human and mouse.
A.
- Normal, Segment of routine EEG on a normal 10-yr-old male with no seizures.
- AS-Deletion, Background EEG of a 9.5-yr-old male, large deletion AS case.
- AS-Non-Deletion, Background EEG of a 10-yr-old male with a UBE3A gene loss-of-function mutation.
The above illustrates that seizures are most severe in AS cases with deletion of the UBE3A gene.
B.
- Background EEGs from mouse littermates (gabrb3+/+ and gabrb3−/−) recorded simultaneously at 2 months of age. Electrodes were placed over right and left parietal cortex and referenced to an electrode placed in the nasal bone. Bottom two EEG traces are representative examples from a gabrb3−/− mouse before (b.) and after (a.) administration of ethosuximide (400 mg/kg). Ethosuximide effectively abolished interictal spiking and normalized EEG background.
Reference
<pubmed>9763493</pubmed>
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Cite this page: Hill, M.A. (2024, April 25) Embryology Electroencephalography of Angelman Syndrome.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Electroencephalography_of_Angelman_Syndrome.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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