File:Developing human cerebellum 01.jpg

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Developing Human Cerebellum

(A–X) A greater EGL cell density and reduced EGL thickness were reported in preterms with ex-utero exposure, as compared to their age matched stillborn controls. ML thickness was increased in preterms with ex-utero exposure born after 34 weeks gestation, as compared to their age matched controls. Compare E with F, G with H and I with J.

Abbreviations

  • wk = number of gestational weeks
  • d = number of postnatal days
  • mon PN = postnatal months - born at term
  • EGL = external granular layer
  • ML = molecular layer
  • PL = purkinje cell layer
  • IGL = internal granular layer

Cresyl violet stained sections

Scale bar = 50 µm (A–L) and 20 µm (M–X).

"A rapid growth in human cerebellar development occurs in the third trimester, which is impeded by preterm delivery. ...We report that premature birth and development in an ex-utero environment leads to a significant decrease in the thickness and an increase in the packing density of the cells within the external granular layer and the inner granular layer well, as a reduction in the density of bergmann glial fibres. In addition, this also leads to a reduced expression of sonic hedgehog in the purkinje layer. We conclude that the developmental program of the cerebellum is specifically modified by events that follow preterm delivery."

Figure 1. Journal.pone.0023449.g001.jpg

Reference

<pubmed>21858122</pubmed>| PLoS One

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current23:21, 22 September 2011Thumbnail for version as of 23:21, 22 September 20111,009 × 1,200 (494 KB)S8600021 (talk | contribs)==Cresyl violet stained sections of the developing human cerebellum== (A–X) A greater EGL cell density and reduced EGL thickness were reported in preterms with ex-utero exposure, as compared to their age matched stillborn controls. ML thickness was inc

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